ArticlePsychiatry research. Neuroimaging2016
The neurobiology of self-knowledge in depressed and self-injurious youth.
Article in Psychiatry research. Neuroimaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Comparative meta-analysis of task-related functional brain abnormalities in nonsuicidal self-injury and suicide attempt.Frontiers in psychiatry · 2026Pooled it
- Abnormal Dynamic Functional Connectivity Within the Fronto-Limbic Network Mediates the Association Between Depressive Symptoms and Non-Suicidal Self-Injury in Adolescents.CNS neuroscience & therapeutics · 2026Article
- Functional heterogeneity in non-suicidal self-injury across psychiatric disorders: neural and psychosocial correlates.Translational psychiatry · 2026Article
- Altered brain function associated with non-suicidal self-injury in adolescents with major depressive disorder: An rs-fMRI study.PloS one · 2026Article
- Understanding the emergence of suicidal thoughts and behaviors in adolescence from a brain and behavioral developmental perspective.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Intractable prefrontal and limbic white matter network disruption in adolescents with drug-naïve nonsuicidal self-injury.BMC psychiatry · 2025Article
- Mediating Effects of Sleep Problems and Emotional Symptoms in the Relationship Between Chronotype and Self-Harm Among Adolescents Aged 11-19 Years.Psychology research and behavior management · 2025Article
- The Relationship Between Perceived Stress, Impulsivity, Executive Dysfunction and Non-Suicidal Self-Injury Thoughts Among Chinese College Students: A Gender Difference Study.Psychology research and behavior management · 2024Article
- A preliminary investigation into cortical structural alterations in adolescents with nonsuicidal self-injury.Psychiatry research. Neuroimaging · 2023Article
- Increased Right Dorsolateral Prefrontal Cortex Connectivity During Emotion Recognition Task in Adolescents With Self-Injurious Behavior: A Functional Near-Infrared Spectroscopy Study.Psychiatry investigation · 2023Article
- Potential mechanisms of non-suicidal self-injury (NSSI) in major depressive disorder: a systematic review.General psychiatry · 2023Article
- A Resting State Functional Magnetic Resonance Imaging Study of Unmedicated Adolescents With Non-suicidal Self-Injury Behaviors: Evidence From the Amplitude of Low-Frequency Fluctuation and Regional Homogeneity Indicator.Frontiers in psychiatry · 2022Article
- Abnormal brain activity in nonsuicidal self-injury: a coordinate-based activation likelihood meta-analysis of functional neuroimaging studies.Psychoradiology · 2021Article
- Neuroimaging Studies of Nonsuicidal Self-Injury in Youth: A Systematic Review.Life (Basel, Switzerland) · 2021Review
- Neural Correlates Associated With Suicide and Nonsuicidal Self-injury in Youth.Biological psychiatry · 2021Review
- Disruption of Neural Activity and Functional Connectivity in Adolescents With Major Depressive Disorder Who Engage in Non-suicidal Self-Injury: A Resting-State fMRI Study.Frontiers in psychiatry · 2021Article
- Amygdala Functional Connectivity During Self-Face Processing in Depressed Adolescents With Recent Suicide Attempt.Journal of the American Academy of Child and Adolescent Psychiatry · 2019Article
- Biological responses to acute stress and suicide: A review and opportunities for methodological innovation.Current behavioral neuroscience reports · 2019Article
- The Development of Self and Identity in Adolescence: Neural Evidence and Implications for a Value-Based Choice Perspective on Motivated Behavior.Child development perspectives · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
There is limited information regarding the neurobiology underlying non-suicidal self-injury (NSSI) in clinically-referred youth. However, the salience of disturbed interpersonal relationships and disrupted self-processing associated with NSSI suggests the neural basis of social processes as a key area for additional study. Adolescent participants (N=123; M=14.75 years, SD=1.64) were divided into three groups: NSSI plus depression diagnosis (NSSI), depression only (DEP), healthy controls (HC). In the scanner, participants completed an Interpersonal Self-Processing task by taking direct (own) and indirect (mothers', best friends', or classmates') perspectives regarding self-characteristics. Across all perspectives, NSSI showed higher BOLD activation in limbic areas, and anterior and posterior cortical midline structures versus DEP and HC, while HC showed greater activity in rostrolateral, frontal pole and occipital cortex than NSSI and DEP youth. Moreover, NSSI youth showed heightened responses in amygdala, hippocampus, parahippocampus, and fusiform when taking their mothers' perspective, which were negatively correlated with self-reports of the mother's support of adolescents' emotional distress in the NSSI group. NSSI youth also yielded greater precuneus and posterior cingulate cortex activity during indirect self-processing from their classmates' perspective. Findings suggest a role for disruptions in self- and emotion-processing, and conflicted social relationships in the neurobiology of NSSI among depressed adolescents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.