Evidence map›Paper›PMID 27442715›Full record

Trial reportAnnals of the American Thoracic Society2016

The Effect of Donepezil on Arousal Threshold and Apnea-Hypopnea Index. A Randomized, Double-Blind, Cross-Over Study.

Yanru Li, Robert L Owens, Scott Sands, Jeremy Orr, Walter Moraes, Pamela DeYoung, Erik Smales, Rachel Jen, Atul Malhotra

Registry-linked trialOpen access · greenAbstract readClinical Trial, Phase IVRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of the American Thoracic Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02264353 (The Impact of Arousal Threshold in Obstructive Sleep Apnea), which is not on this map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02264353 phase4completednot on this map

The Impact of Arousal Threshold in Obstructive Sleep Apnea: Donepezil's Effects on the Arousal Threshold and on the Apnea Hypopnea Index

TypeinterventionalSponsorUniversity of California, San DiegoRan2014 to 2015Enrolled44ConditionsObstructive Sleep ApneaArmsDonepezil, placebo
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023
    Review
  10. Article
  11. Obstructive sleep apnea.Handbook of clinical neurology · 2022
    Review
  12. Review
  13. Personalised medicine in sleep respiratory disorders: focus on obstructive sleep apnoea diagnosis and treatment.European respiratory review : an official journal of the European Respiratory Society · 2017
    Review
  14. Impact of concomitant medications on obstructive sleep apnoea.British journal of clinical pharmacology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 5 countries.

Yanru Li1 Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Robert L Owens2 Division of Pulmonary and Critical Care Medicine, University of California, San Diego, La Jolla, California.
Scott Sands3 Division of Sleep Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Jeremy Orr2 Division of Pulmonary and Critical Care Medicine, University of California, San Diego, La Jolla, California.
Walter Moraes5 Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil; and.
Pamela DeYoung2 Division of Pulmonary and Critical Care Medicine, University of California, San Diego, La Jolla, California.
Erik Smales2 Division of Pulmonary and Critical Care Medicine, University of California, San Diego, La Jolla, California.
Rachel Jen2 Division of Pulmonary and Critical Care Medicine, University of California, San Diego, La Jolla, California.
Atul Malhotra2 Division of Pulmonary and Critical Care Medicine, University of California, San Diego, La Jolla, California.
University of California San Diego · USBeijing Tongren Hospital · CNBrigham and Women's Hospital · USUniversidade Federal de São Paulo · BRUniversity of British Columbia · CA

Funding

Neural Plasticity During Acclimatization to HypoxiaR01HL081823 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI POWELL, FRANK L. · 2005 to 2019
$4.5M
Single Motor Unit Genioglossus Recordings to Understand Sleep Apnea PathogenesisR01HL085188 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2008 to 2018
$3.5M
Imaging Blood Flow, Ventilation, and Density InteractionsR01HL119201 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HOPKINS, SUSAN R · 2016 to 2019
$2.5M
Training in the Next Generation in Respiratory ScienceT32HL134632 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, POWELL, FRANK L. · 2017 to 2021
$2.1M
Assessment of Upper Airway Mechanics Using Newer Electromyographic TechniquesK24HL132105 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2016 to 2020
$611k
MR Imaging of Upper Airway Dynamics in Obstructive Sleep ApneaR21HL121794 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DARQUENNE, CHANTAL · 2014 to 2015
$423k
NHLBI NIH HHS K24 HL132105NHLBI NIH HHS R01 HL081823NHLBI NIH HHS R01 HL085188NHLBI NIH HHS R01 HL119201NHLBI NIH HHS R21 HL121794NHLBI NIH HHS T32 HL134632
6 · The paper itself

Abstract

rationaleObstructive sleep apnea (OSA) has multiple pathophysiological causes. A low respiratory arousal threshold (ArTh) and a high loop gain (unstable ventilatory control) can contribute to recurrent respiratory events in patients with OSA. Prior studies have shown that donepezil, an acetylcholinesterase inhibitor, might improve OSA, but the mechanism is unknown.

objectivesTo determine whether a single dose of donepezil lowers the apnea-hypopnea index by modulating the ArTh or loop gain.

methodsIn this randomized, double-blind, crossover trial, 41 subjects with OSA underwent two polysomnograms with ArTh and loop gain evaluated, during which 10 mg of donepezil or placebo was administered. MEASUREMENTS AND MAIN

resultsCompared with placebo, sleep efficiency (77.2 vs. 71.9%; P = 0.015) and total sleep time decreased with donepezil (372 vs. 351 min; P = 0.004). No differences were found in apnea-hypopnea index (51.8 vs. 50.0 events/h; P = 0.576) or nadir oxygen saturation as determined by pulse oximetry (80.3 vs. 81.1%; P = 0.241) between placebo and donepezil, respectively. ArTh was not significantly changed (-18.9 vs. -18.0 cm H

conclusionsA single dose of donepezil did not appear to affect the overall severity of OSA in this patient group, and no consistent effects on ArTh or loop gain were observed. Donepezil may have minor effects on sleep architecture. Clinical trial registered with www.clinicaltrials.gov (NCT02264353).

Indexed as

AdultArousalCaliforniaCholinesterase InhibitorsCross-Over StudiesDonepezilDouble-Blind MethodFemaleHumansIndansMaleMiddle AgedOximetryPiperidinesPolysomnographyRespiratory SystemCholinesterase InhibitorsDonepezilIndansPiperidinesarousal thresholddonepezilloop gainobstructive sleep apneatreatment

Identifiers

PMID27442715
PMCPMC5122481
OpenAlexW2503297002

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.