ArticlePloS one2016
Pregnancy Outcomes in Chinese Patients with Systemic Lupus Erythematosus (SLE): A Retrospective Study of 109 Pregnancies.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Dual BAFF/APRIL inhibition with telitacicept in systemic lupus erythematosus and IgA nephropathy: pharmacological rationale, clinical efficacy, and safety on female fertility preservation.Frontiers in pharmacology · 2026Pooled it
- Humoral immunity and safety of respiratory virus vaccines in systemic lupus erythematosus population: a meta-analysis based on twenty-five observational studies.Annals of medicine · 2024Pooled it
- Pregnancy characteristics in patients with autoimmune diseases with different onset times and their relationship with pregnancy outcomes.BMC pregnancy and childbirth · 2026Article
- Pregnancy characteristics of patients with systemic lupus erythematosus with different onset times and their risk of adverse pregnancy outcomes: a retrospective cohort study.Lupus science & medicine · 2025Article
- Pregnancy Outcomes in a Diverse US Lupus Cohort.Arthritis care & research · 2024Article
- Effects of perinatal disease activity on offspring's growth in patients with systemic lupus erythematosus.Archives of medical science : AMS · 2024Article
- Miscarriage-Related Acute Kidney Injury: A Case Report.International medical case reports journal · 2024Article
- Preparing for Pregnancy in Women with Systemic Lupus Erythematosus-A Multidisciplinary Approach.Medicina (Kaunas, Lithuania) · 2022Review
- Systemic Lupus Erythematosus and Pregnancy: a Portuguese Case-Control Study.Clinical reviews in allergy & immunology · 2022Article
- Pregnancy outcomes in patients with systemic lupus erythematosus with or without a history of lupus nephritis.Clinical and experimental nephrology · 2021Article
- Clinical features of new-onset systemic lupus erythematosus during pregnancy in Central China: a retrospective study of 68 pregnancies.Clinical rheumatology · 2021Review
- Outcomes of pregnancy and associated factors in sub-Saharan African women with systemic lupus erythematosus: a scoping review.Lupus science & medicine · 2020Article
- Prediction of fetal loss in Chinese pregnant patients with systemic lupus erythematosus: a retrospective cohort study.BMJ open · 2019Observational
- Predictors of SLE relapse in pregnancy and post-partum among multi-ethnic patients in Malaysia.PloS one · 2019Article
- Management and outcomes of pregnancy with or without lupus nephritis: a systematic review and meta-analysis.Therapeutics and clinical risk management · 2018Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that primarily affects women during their reproductive years. The interaction between SLE and pregnancy remains debated. The objective of this study was to analyze the fetal and maternal outcomes of Chinese women with SLE. A total of 109 pregnancies in 83 SLE patients from June 2004 to June 2014 at a tertiary university hospital were reviewed retrospectively. Patients' characteristics, clinical and laboratory data during pregnancy were obtained from electronic medical records. After exclusion of elective abortions, the live birth rate was 61.5%. Significantly, APS (antiphospholipid syndrome), disease activity, hypertension, hypocomplementemia, thrombocytopenia, and anemia during pregnancy were more commonly observed in fetal loss pregnancies than in live birth pregnancies. Compared to the 64 women with a history of SLE, 19 women with new-onset lupus during pregnancy had worse pregnancy outcome. Furthermore, the 64 patients with a history of SLE were divided into lupus nephritis group and SLE group (non-renal involvement). We found that the lupus nephritis group had worse maternal outcome than the SLE group. We conclude that new-onset lupus during pregnancy predicts both adverse maternal and fetal outcomes, while a history of lupus nephritis predicts adverse maternal outcomes. It is essential to provide SLE women with progestational counseling and regular multispecialty care during pregnancy.
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