ArticleInvestigative ophthalmology & visual science2016
Peripapillary Retinal Nerve Fiber Layer Vascular Microcirculation in Glaucoma Using Optical Coherence Tomography-Based Microangiography.
Article in Investigative ophthalmology & visual science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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The trial behind it
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Who cites it
80 citing papers in PubMed, 147 citations in OpenAlex.
- Correlation between OCT-angiography and photopic negative response in patients with primary open angle glaucoma.International ophthalmology · 2023Trial
- A Comparison of Vessel Density in Primary Open-Angle Glaucoma and Normal-Tension Glaucoma Patients Using OCT Angiography.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Evaluation of OCT Angiography Parameters as Biomarkers for Glaucoma Progression.Diagnostics (Basel, Switzerland) · 2025Article
- Assessment of Retinal Microcirculation in Primary Open-Angle Glaucoma Using Adaptive Optics and OCT Angiography: Correlation with Structural and Functional Damage.Journal of clinical medicine · 2025Article
- Diabetes-Induced Dysregulation of Peripapillary and Macular Neurovascular Units.Investigative ophthalmology & visual science · 2025Article
- Visible-light optical coherence tomography and its applications.Neurophotonics · 2025Review
- Vascular Density and Retinal Structure Relationships Across Sectors and Regions of the Optic Nerve in Patients With Primary Open Angle Glaucoma.Journal of glaucoma · 2025Article
- Evaluating the predictive value of optical coherence tomography angiography metrics and central corneal thickness among glaucoma suspect patients: a comparative cross-sectional study.Medical hypothesis, discovery & innovation ophthalmology journal · 2025Article
- Peripapillary Perfusion Analysis Using Optical Coherence Tomography Angiography in Patients with Normal Tension Glaucoma.Korean journal of ophthalmology : KJO · 2024Article
- Efficacy and safety of platelet-rich plasma for acute nonarteritic anterior ischemic optic neuropathy: a prospective cohort study.Frontiers in medicine · 2024Article
- Peripapillary and macular vascular parameters by optical coherence tomography angiography in primary congenital glaucoma.Eye (London, England) · 2023Article
- Optical Coherence Tomography Angiography (OCTA) Differences in Vessel Perfusion Density and Flux Index of the Optic Nerve and Peri-Papillary Area in Healthy, Glaucoma Suspect and Glaucomatous Eyes.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- Optic nerve head vascular variations in pseudoexfoliative and primary open-angle glaucoma.Arquivos brasileiros de oftalmologia · 2023Observational
- Fractal Dimension of Peripapillary Vasculature in Primary Open-Angle Glaucoma.Korean journal of ophthalmology : KJO · 2022Article
- Depth-resolved extraction of optical attenuation for glaucoma assessment in clinical settings: a pilot study.Biomedical optics express · 2022Article
- Vascular biomarkers from optical coherence tomography angiography and glaucoma: where do we stand in 2021?Acta ophthalmologica · 2022Review
- Analysis of retinal vasculature changes in indirect traumatic optic neuropathy using optic coherence tomography angiography.International journal of ophthalmology · 2022Article
- Optical Microangiography and Progressive Retinal Nerve Fiber Layer Loss in Primary Open Angle Glaucoma.American journal of ophthalmology · 2022Article
- Long-term repeatability of peripapillary optical coherence tomography angiography measurements in healthy eyes.Scientific reports · 2021Observational
- Combining OCT and OCTA for Focal Structure-Function Modeling in Early Primary Open-Angle Glaucoma.Investigative ophthalmology & visual science · 2021Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeTo investigate the vascular microcirculation changes in the retinal nerve fiber layer (RNFL) in normal, glaucoma suspect, and open-angle glaucoma (OAG) groups using optical coherence tomography-based microangiography (OMAG).
methodsOne eye from each subject was scanned with a Cirrus HD-OCT 5000-based OMAG prototype system montage scanning protocol centered at the optic nerve head (ONH). Blood flow signals were extracted using OMAG algorithm. Retinal nerve fiber layer vascular microcirculation was measured by calculating the blood flux index and vessel area density within a 1.2-mm width annulus centered at the ONH with exclusion of big retinal vessels. One-way ANOVA were performed to analyze the RNFL microcirculation among groups. Linear-regression models were constructed to analyze the correlation between RNFL microcirculation and clinical parameters. Discrimination capabilities of the flow metrics were assessed with the area under the receiver operating characteristic curve (AROC).
resultsTwenty normal, 26 glaucoma suspect, and 42 OAG subjects were enrolled. Eyes from OAG subjects and glaucoma suspects showed significantly lower blood flux index compared with normal eyes (P ≤ 0.0015). Retinal nerve fiber layer blood flow metrics showed significant correlations with visual field indices and structural changes in glaucomatous eyes (P ≤ 0.0123). Similar discrimination capability of blood flux index compared with RNFL thickness was found in both disease groups.
conclusionsPeripapillary RNFL vascular microcirculation measured as blood flux index by OMAG showed significant differences among OAG, glaucoma suspect, and normal controls and was significantly correlated with functional and structural defects. Retinal nerve fiber layer microcirculation measurement using OMAG may help physicians monitor glaucoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.