ArticleNature chemistry2016
High-resolution mapping of bifurcations in nonlinear biochemical circuits.
Article in Nature chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
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- Molecular systems engineering of synthetic cells.Nature chemistry · 2026Review
- Interpretable molecular decision-making with DNA-based scalable and memory-efficient tree computation.Nature communications · 2025Article
- Implementing complex nucleic acid circuits in living cells.Science advances · 2025Article
- Bistable Functions and Signaling Motifs in Systems Chemistry: Taking the Next Step Toward Synthetic Cells.Accounts of chemical research · 2025Review
- High-Speed Sequential DNA Computing Using a Solid-State DNA Origami Register.ACS central science · 2024Article
- DNA-empowered synthetic cells as minimalistic life forms.Nature reviews. Chemistry · 2024Review
- DNA as a universal chemical substrate for computing and data storage.Nature reviews. Chemistry · 2024Review
- DNA droplets for intelligent and dynamical artificial cells: from the viewpoint of computation and non-equilibrium systems.Interface focus · 2023Review
- Micro-compartmentalized strand displacement reactions with a random pool background.Interface focus · 2023Article
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- Cell-Free Production Systems in Droplet Microfluidics.Advances in biochemical engineering/biotechnology · 2023Review
- Standardized excitable elements for scalable engineering of far-from-equilibrium chemical networks.Nature chemistry · 2022Article
- A deep artificial neural network powered by enzymes.Nature · 2022Article
- Programmable synthetic cell networks regulated by tuneable reaction rates.Nature communications · 2022Article
- Complex dynamics in a synchronized cell-free genetic clock.Nature communications · 2022Article
- Controlling the Synchronization of Molecular Oscillators through Indirect Coupling.Micromachines · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Analog molecular circuits can exploit the nonlinear nature of biochemical reaction networks to compute low-precision outputs with fewer resources than digital circuits. This analog computation is similar to that employed by gene-regulation networks. Although digital systems have a tractable link between structure and function, the nonlinear and continuous nature of analog circuits yields an intricate functional landscape, which makes their design counter-intuitive, their characterization laborious and their analysis delicate. Here, using droplet-based microfluidics, we map with high resolution and dimensionality the bifurcation diagrams of two synthetic, out-of-equilibrium and nonlinear programs: a bistable DNA switch and a predator-prey DNA oscillator. The diagrams delineate where function is optimal, dynamics bifurcates and models fail. Inverse problem solving on these large-scale data sets indicates interference from enzymatic coupling. Additionally, data mining exposes the presence of rare, stochastically bursting oscillators near deterministic bifurcations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.