ArticlePloS one2016
Contribution of the Collagen-Binding Proteins of Streptococcus mutans to Bacterial Colonization of Inflamed Dental Pulp.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Oral, gut, and skin microbiota characterization in patients with heart valve disease with or without infective endocarditis: a pilot study.Microbiology spectrum · 2026Observational
- TheApplied and environmental microbiology · 2026Article
- Diversity of Streptococcus mutans serotypes isolated from dental plaque of Brazilian patients with a history of acute myocardial infarction.Journal of applied oral science : revista FOB · 2026Article
- Evaluation of Streptococcus mutans strains possessing genes encoding collagen-binding proteins in the Japanese population.BMC oral health · 2025Article
- Prevalence of Streptococcus mutans harboring the cnm gene encoding cell surface protein Cnm in Japanese children.Scientific reports · 2025Article
- Glycosylation of oral bacteria in modulating adhesion and biofilm formation.Journal of oral microbiology · 2025Review
- Leaf Extracts ofTheScientificWorldJournal · 2024Article
- Involvement of the Streptococcus mutans PgfE and GalE 4-epimerases in protein glycosylation, carbon metabolism, and cell division.Glycobiology · 2023Article
- Clinical characteristics of children and guardians possessing CBP-positive Streptococcus mutans strains: a cross-sectional study.Scientific reports · 2022Article
- Detection of Streptococcus mutans in symptomatic and asymptomatic infected root canals.Clinical oral investigations · 2021Article
- Collagen Binding Proteins of Gram-Positive Pathogens.Frontiers in microbiology · 2021Review
- The oralome and its dysbiosis: New insights into oral microbiome-host interactions.Computational and structural biotechnology journal · 2021Review
- Phenotypic and Genotypic Characterization of Streptococcus mutans Strains Isolated from Endodontic Infections.Journal of endodontics · 2020Article
- Oral Carriage ofStroke · 2020Article
- Bioadhesion in the oral cavity and approaches for biofilm management by surface modifications.Clinical oral investigations · 2020Review
- Contribution of Severe Dental Caries Induced by Streptococcus mutans to the Pathogenicity of Infective Endocarditis.Infection and immunity · 2020Article
- Antimicrobial Activity of Nano-Magnesium Hydroxide Against Oral Bacteria and Application in Root Canal Sealer.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Infection of Human Dental Pulp Stromal Cells byFrontiers in cell and developmental biology · 2020Article
- Haemophilus parasuis VtaA2 is involved in adhesion to extracellular proteins.Veterinary research · 2019Article
- Relationship betweenBMJ open gastroenterology · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus mutans is a major pathogen of dental caries. Collagen-binding proteins (CBPs) (approximately 120 kDa), termed Cnm and Cbm, are regarded as important cell surface antigens related to the adherence of S. mutans to collagenous tissue. Furthermore, CBP-positive S. mutans strains are associated with various systemic diseases involving bacteremia, such as infective endocarditis. Endodontic infection is considered to be an important cause of bacteremia, but little is known regarding the presence of S. mutans in dental pulp tissue. In the present study, the distribution and virulence of S. mutans in dental pulp tissues were investigated by focusing on CBPs. Adhesion and invasion properties of various S. mutans strains were analyzed using human dental pulp fibroblasts (HDPFs). CBP-positive strains had a significantly higher rate of adhesion to HDPFs compared with CBP-defective isogenic mutant strains (P<0.001). In addition, CBP-positive strains induced HDPF proliferation, which is a possible mechanism related to development of hyperplastic pulpitis. The distribution of S. mutans strains isolated from infected root canal specimens was then analyzed by PCR. We found that approximately 50% of the root canal specimens were positive for S. mutans. Approximately 20% of these strains were Cnm-positive, while no Cbm-positive strains were isolated. The Cnm-positive strains isolated from the specimens showed adhesion to HDPFs. Our results suggest that CBP-positive S. mutans strains exhibit high colonization in dental pulp. This could be a possible virulence factor for various systemic diseases.
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