ArticlePloS one2016
First Case of Legionnaire's Disease Caused by Legionella anisa in Spain and the Limitations on the Diagnosis of Legionella non-pneumophila Infections.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Risk Communication and Infodemic Misframing inMicroorganisms · 2026Article
- Occurrence of UnculturedPathogens (Basel, Switzerland) · 2024Article
- The Contribution ofInternational journal of environmental research and public health · 2024Article
- Opportunistic Pathogens in Drinking Water Distribution Systems-A Review.Microorganisms · 2024Review
- Occurrence and prevalence of Legionella species in dental chair units in Germany with a focus on risk factors.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023Article
- Case report of arthritis caused by Legionella anisa and review of the literature.BMC infectious diseases · 2022Review
- Legionnaires' Disease: Update on Diagnosis and Treatment.Infectious diseases and therapy · 2022Review
- Dynamics of Legionella Community Interactions in Response to Temperature and Disinfection Treatment: 7 Years of Investigation.Microbial ecology · 2022Article
- Genomic characterization and assessment of pathogenic potential ofFrontiers in microbiology · 2022Article
- New Insight regardingMicrobiology spectrum · 2021Article
- Occurrence of the Legionella species in the respiratory samples of patients with pneumonia symptoms from Ahvaz, Iran; first detection of Legionella cherrii.Molecular biology reports · 2021Article
- Intracellular Behaviour ofPathogens (Basel, Switzerland) · 2021Article
- Article
- How Molecular Typing Can SupportInternational journal of environmental research and public health · 2020Article
- Chlorine Disinfection ofMicroorganisms · 2020Article
- Evaluation of MALDI-TOF Mass Spectrometry in Diagnostic and Environmental Surveillance ofFrontiers in microbiology · 2020Article
- Improvement of Legionnaires' disease diagnosis using real-time PCR assay: a retrospective analysis, Italy, 2010 to 2015.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2018Article
- Detection ofMicroorganisms · 2018Article
- Cross-transmission in the Dental Office: Does This Make You Ill?Current oral health reports · 2018Review
- Article
Corrections and comments
- Erratum issuedCorrection: First Case of Legionnaire's Disease Caused by Legionella anisa in Spain and the Limitations on the Diagnosis of Legionella non-pneumophila Infections.2016 · Salinas, Mireya A [corrected to Salinas, Mireya B]
Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Legionnaires' disease is a severe form of pneumonia, with worldwide relevance, caused by Legionella spp. Approximately 90% of all cases of legionellosis are caused by Legionella pneumophila, but other species can also be responsible for this infection. These bacteria are transmitted by inhalation of aerosols or aspiration of contaminated water. In Spain, environmental studies have demonstrated the presence of Legionella non-pneumophila species in drinking water treatment plants and water distribution networks. Aware that this evidence indicates a risk factor and the lack of routine assays designed to detect simultaneously diverse Legionella species, we analyzed 210 urine samples from patients presenting clinical manifestations of pneumonia using a semi-nested PCR for partial amplification of the 16S rDNA gene of Legionella and a diagnostic method used in hospitals for Legionella antigen detection. In this study, we detected a total of 15 cases of legionellosis (7.1%) and the first case of Legionnaires' disease caused by L. anisa in Spain. While the conventional method used in hospitals could only detect four cases (1.9%) produced by L. pneumophila serogroup 1, using PCR, the following species were identified: Legionella spp. (10/15), L. pneumophila (4/15) and L. anisa (1/15). These results suggest the need to change hospital diagnostic strategies regarding the identification of Legionella species associated with this disease. Therefore, the detection of Legionella DNA by PCR in urine samples seems to be a suitable alternative method for a sensitive, accurate and rapid diagnosis of Legionella pneumonia, caused by L. pneumophila and also for L. non-pneumophila species.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.