ArticleEndocrinology2016
FKBP51 Null Mice Are Resistant to Diet-Induced Obesity and the PPARγ Agonist Rosiglitazone.
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Article in Endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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54citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
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Who cites it
54 citing papers in PubMed, 99 citations in OpenAlex.
- Dual proximity-based interactome mapping of FKBP51 and FKBP52 uncovers shared metabolic networks.Biochemical and biophysical research communications · 2026Article
- Inhibition of FKBP51 alleviates depressive-like behaviors via AKT/mTOR-dependent autophagy and synaptic plasticity.The international journal of neuropsychopharmacology · 2026Article
- FKBP51 disrupts the insulin signaling pathway and impairs mitochondrial bioenergetics in HepG2 cells.Scientific reports · 2026Article
- FK506-binding protein-5 in high-fat diet-induced metabolic dysfunction-associated steatotic liver disease.Scientific reports · 2026Article
- Unraveling Complex Interactions Mechanisms Linking PTSD and Chronic Diseases.Current neuropharmacology · 2026Review
- Analgesia through FKBP51 inhibition at disease onset confers lasting relief from sensory and emotional chronic pain symptoms.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The physiology of MASLD: molecular pathways between liver and adipose tissues.Clinical science (London, England : 1979) · 2025Review
- Heme oxygenase, biliverdin reductase, and bilirubin pathways regulate oxidative stress and insulin resistance: a focus on diabetes and therapeutics.Clinical science (London, England : 1979) · 2025Review
- Article
- Adipose stem cells are sexually dimorphic cells with dual roles as preadipocytes and resident fibroblasts.Nature communications · 2024Article
- Paternal high-fat diet affects weight and DNA methylation of their offspring.Scientific reports · 2024Article
- Glucocorticoid resistance remodels liver lipids and prompts lipogenesis, eicosanoid, and inflammatory pathways.Prostaglandins & other lipid mediators · 2024Review
- Bta-miR-365-3p-targeted FK506-binding protein 5 participates in the AMPK/mTOR signaling pathway in the regulation of preadipocyte differentiation in cattle.Animal bioscience · 2024Article
- The Role of FKBPs in Complex Disorders: Neuropsychiatric Diseases, Cancer, and Type 2 Diabetes Mellitus.Cells · 2024Review
- Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells.Cell communication and signaling : CCS · 2024Article
- Automated Flow Peptide Synthesis Enables Engineering of Proteins with Stabilized Transient Binding Pockets.ACS central science · 2024Article
- FKBP51-Hsp90 Interaction-Deficient Mice Exhibit Altered Endocrine Stress Response and Sex Differences Under High-Fat Diet.Molecular neurobiology · 2024Article
- Knocking out Fkbp51 decreases CClCell & bioscience · 2024Article
- Glucocorticoids, their uses, sexual dimorphisms, and diseases: new concepts, mechanisms, and discoveries.Physiological reviews · 2024Review
- Single-nucleus transcriptomics of epicardial adipose tissue from females reveals exercise control of innate and adaptive immune cells.bioRxiv : the preprint server for biology · 2023Article
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Authors and funding
13 authors at 3 institutions in 2 countries.
Lance A StechschulteDepartments of Physiology and Pharmacology (L.A.S., M.W., T.D.H., S.S.K., L.R., S.M.N., B.L.-C., E.R.S.) and Orthopaedic Surgery (L.A.S., B.L.-C.) and the Center for Diabetes and Endocrine Research (L.A.S., M.W., T.D.H., S.K., L.R., S.M.N., B.L.-C., E.R.S.), University of Toledo College of Medicine and Life Sciences, Toledo, Ohio 43614-5804; Department of Gene and Development (B.Q., M.Z., H.G., Y.X., W.Y.), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China; and Department of Nutrition (M.W.), Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina 27599.
Bin QiuDepartments of Physiology and Pharmacology (L.A.S., M.W., T.D.H., S.S.K., L.R., S.M.N., B.L.-C., E.R.S.) and Orthopaedic Surgery (L.A.S., B.L.-C.) and the Center for Diabetes and Endocrine Research (L.A.S., M.W., T.D.H., S.K., L.R., S.M.N., B.L.-C., E.R.S.), University of Toledo College of Medicine and Life Sciences, Toledo, Ohio 43614-5804; Department of Gene and Development (B.Q., M.Z., H.G., Y.X., W.Y.), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China; and Department of Nutrition (M.W.), Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina 27599.
Manya WarrierDepartments of Physiology and Pharmacology (L.A.S., M.W., T.D.H., S.S.K., L.R., S.M.N., B.L.-C., E.R.S.) and Orthopaedic Surgery (L.A.S., B.L.-C.) and the Center for Diabetes and Endocrine Research (L.A.S., M.W., T.D.H., S.K., L.R., S.M.N., B.L.-C., E.R.S.), University of Toledo College of Medicine and Life Sciences, Toledo, Ohio 43614-5804; Department of Gene and Development (B.Q., M.Z., H.G., Y.X., W.Y.), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China; and Department of Nutrition (M.W.), Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina 27599.
Terry D HindsDepartments of Physiology and Pharmacology (L.A.S., M.W., T.D.H., S.S.K., L.R., S.M.N., B.L.-C., E.R.S.) and Orthopaedic Surgery (L.A.S., B.L.-C.) and the Center for Diabetes and Endocrine Research (L.A.S., M.W., T.D.H., S.K., L.R., S.M.N., B.L.-C., E.R.S.), University of Toledo College of Medicine and Life Sciences, Toledo, Ohio 43614-5804; Department of Gene and Development (B.Q., M.Z., H.G., Y.X., W.Y.), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China; and Department of Nutrition (M.W.), Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina 27599.
Man ZhangDepartments of Physiology and Pharmacology (L.A.S., M.W., T.D.H., S.S.K., L.R., S.M.N., B.L.-C., E.R.S.) and Orthopaedic Surgery (L.A.S., B.L.-C.) and the Center for Diabetes and Endocrine Research (L.A.S., M.W., T.D.H., S.K., L.R., S.M.N., B.L.-C., E.R.S.), University of Toledo College of Medicine and Life Sciences, Toledo, Ohio 43614-5804; Department of Gene and Development (B.Q., M.Z., H.G., Y.X., W.Y.), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China; and Department of Nutrition (M.W.), Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina 27599.
Hao GuDepartments of Physiology and Pharmacology (L.A.S., M.W., T.D.H., S.S.K., L.R., S.M.N., B.L.-C., E.R.S.) and Orthopaedic Surgery (L.A.S., B.L.-C.) and the Center for Diabetes and Endocrine Research (L.A.S., M.W., T.D.H., S.K., L.R., S.M.N., B.L.-C., E.R.S.), University of Toledo College of Medicine and Life Sciences, Toledo, Ohio 43614-5804; Department of Gene and Development (B.Q., M.Z., H.G., Y.X., W.Y.), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China; and Department of Nutrition (M.W.), Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina 27599.
Yuxue XuDepartments of Physiology and Pharmacology (L.A.S., M.W., T.D.H., S.S.K., L.R., S.M.N., B.L.-C., E.R.S.) and Orthopaedic Surgery (L.A.S., B.L.-C.) and the Center for Diabetes and Endocrine Research (L.A.S., M.W., T.D.H., S.K., L.R., S.M.N., B.L.-C., E.R.S.), University of Toledo College of Medicine and Life Sciences, Toledo, Ohio 43614-5804; Department of Gene and Development (B.Q., M.Z., H.G., Y.X., W.Y.), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China; and Department of Nutrition (M.W.), Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina 27599.
Saja S KhuderDepartments of Physiology and Pharmacology (L.A.S., M.W., T.D.H., S.S.K., L.R., S.M.N., B.L.-C., E.R.S.) and Orthopaedic Surgery (L.A.S., B.L.-C.) and the Center for Diabetes and Endocrine Research (L.A.S., M.W., T.D.H., S.K., L.R., S.M.N., B.L.-C., E.R.S.), University of Toledo College of Medicine and Life Sciences, Toledo, Ohio 43614-5804; Department of Gene and Development (B.Q., M.Z., H.G., Y.X., W.Y.), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China; and Department of Nutrition (M.W.), Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina 27599.
Lucia RussoDepartments of Physiology and Pharmacology (L.A.S., M.W., T.D.H., S.S.K., L.R., S.M.N., B.L.-C., E.R.S.) and Orthopaedic Surgery (L.A.S., B.L.-C.) and the Center for Diabetes and Endocrine Research (L.A.S., M.W., T.D.H., S.K., L.R., S.M.N., B.L.-C., E.R.S.), University of Toledo College of Medicine and Life Sciences, Toledo, Ohio 43614-5804; Department of Gene and Development (B.Q., M.Z., H.G., Y.X., W.Y.), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China; and Department of Nutrition (M.W.), Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina 27599.
Sonia M NajjarDepartments of Physiology and Pharmacology (L.A.S., M.W., T.D.H., S.S.K., L.R., S.M.N., B.L.-C., E.R.S.) and Orthopaedic Surgery (L.A.S., B.L.-C.) and the Center for Diabetes and Endocrine Research (L.A.S., M.W., T.D.H., S.K., L.R., S.M.N., B.L.-C., E.R.S.), University of Toledo College of Medicine and Life Sciences, Toledo, Ohio 43614-5804; Department of Gene and Development (B.Q., M.Z., H.G., Y.X., W.Y.), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China; and Department of Nutrition (M.W.), Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina 27599.
Beata Lecka-CzernikDepartments of Physiology and Pharmacology (L.A.S., M.W., T.D.H., S.S.K., L.R., S.M.N., B.L.-C., E.R.S.) and Orthopaedic Surgery (L.A.S., B.L.-C.) and the Center for Diabetes and Endocrine Research (L.A.S., M.W., T.D.H., S.K., L.R., S.M.N., B.L.-C., E.R.S.), University of Toledo College of Medicine and Life Sciences, Toledo, Ohio 43614-5804; Department of Gene and Development (B.Q., M.Z., H.G., Y.X., W.Y.), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China; and Department of Nutrition (M.W.), Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina 27599.
Weidong YongDepartments of Physiology and Pharmacology (L.A.S., M.W., T.D.H., S.S.K., L.R., S.M.N., B.L.-C., E.R.S.) and Orthopaedic Surgery (L.A.S., B.L.-C.) and the Center for Diabetes and Endocrine Research (L.A.S., M.W., T.D.H., S.K., L.R., S.M.N., B.L.-C., E.R.S.), University of Toledo College of Medicine and Life Sciences, Toledo, Ohio 43614-5804; Department of Gene and Development (B.Q., M.Z., H.G., Y.X., W.Y.), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China; and Department of Nutrition (M.W.), Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina 27599.
Edwin R SanchezDepartments of Physiology and Pharmacology (L.A.S., M.W., T.D.H., S.S.K., L.R., S.M.N., B.L.-C., E.R.S.) and Orthopaedic Surgery (L.A.S., B.L.-C.) and the Center for Diabetes and Endocrine Research (L.A.S., M.W., T.D.H., S.K., L.R., S.M.N., B.L.-C., E.R.S.), University of Toledo College of Medicine and Life Sciences, Toledo, Ohio 43614-5804; Department of Gene and Development (B.Q., M.Z., H.G., Y.X., W.Y.), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China; and Department of Nutrition (M.W.), Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina 27599.
University of Toledo · USChinese Academy of Medical Sciences & Peking Union Medical College · CNUniversity of North Carolina at Chapel Hill · US
Funding
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUSAN M. SMITH · 1999 to 2026
$31.6MRegional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Martin G Myers · 2013 to 2026
$24.3MSUBSTRATES AND INSULIN RECEPTOR ENDOCYTOSISR01DK054254 · NIDDK · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI NAJJAR, SONIA M. · 2000 to 2021
$5.8MPRIDE: Functional and Translational Genomics of Blood DisordersR25HL106365 · NHLBI · AUGUSTA UNIVERSITY · PI PACE, BETTY SUE · 2010 to 2024
$5.2MCEACAM1: A link between metabolic and cardiovascular diseasesR01HL112248 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI NAJJAR, SONIA M. · 2012 to 2016
$1.9MTPR Proteins in Steroid Receptor Signaling &PhysiologyR01DK070127 · NIDDK · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI SANCHEZ, EDWIN RAMON · 2005 to 2009
$1.3MAntioxidant-PPARalpha interaction and hypertensionK01HL125445 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI HINDS, TERRY D · 2015 to 2019
$779kInsulin resistance in the pathogenesis of NASHR01DK083850 · NIDDK · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI NAJJAR, SONIA M. · 2009 to 2010
$749kNHLBI NIH HHS K01 HL125445NHLBI NIH HHS R01 HL112248NHLBI NIH HHS R25 HL106365NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK056350NIDDK NIH HHS R01 DK054254NIDDK NIH HHS R01 DK070127NIDDK NIH HHS R01 DK083850NIMHD NIH HHS L32 MD009154
Abstract
FK506-binding protein-51 (FKBP51) is a molecular cochaperone recently shown to be a positive regulator of peroxisome proliferator-activated receptor (PPAR)γ, the master regulator of adipocyte differentiation and function. In cellular models of adipogenesis, loss of FKBP51 not only reduced PPARγ activity but also reduced lipid accumulation, suggesting that FKBP51 knock-out (KO) mice might have insufficient development of adipose tissue and lipid storage ability. This model was tested by examining wild-type (WT) and FKBP51-KO mice under regular and high-fat diet conditions. Under both diets, FKBP51-KO mice were resistant to weight gain, hepatic steatosis, and had greatly reduced white adipose tissue (WAT) but higher amounts of brown adipose tissue. Under high-fat diet, KO mice were highly resistant to adiposity and exhibited reduced plasma lipids and elevated glucose and insulin tolerance. Profiling of perigonadal and sc WAT revealed elevated expression of brown adipose tissue lineage genes in KO mice that correlated increased energy expenditure and a shift of substrate oxidation to carbohydrates, as measured by indirect calorimetry. To directly test PPARγ involvement, WT and KO mice were fed rosiglitazone agonist. In WT mice, rosiglitazone induced whole-body weight gain, increased WAT mass, a shift of substrate oxidation to lipids, and elevated expression of PPARγ-regulated lipogenic genes in WAT. In contrast, KO mice had reduced rosiglitazone responses for these parameters. Our results identify FKBP51 as an important regulator of PPARγ in WAT and as a potential new target in the treatment of obesity and diabetes.
Indexed as
Glucose IntoleranceLipid MetabolismAdiposityAnimalsEnergy MetabolismFatty LiverIntra-Abdominal FatLipidsMaleMice, KnockoutObesityPPAR gammaRosiglitazoneTacrolimus Binding Protein 5Tacrolimus Binding ProteinsThiazolidinedionesLipidsPPAR gammaRosiglitazoneTacrolimus Binding Protein 5Tacrolimus Binding ProteinsThiazolidinediones
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