ArticlePloS one2016
Whole Genome Sequencing Allows Better Understanding of the Evolutionary History of Leptospira interrogans Serovar Hardjo.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Divergent Fates of Hardjo Leptospires: Early Transcriptomic Response ofTransboundary and emerging diseases · 2026Article
- Shaping the future ofJournal of medical microbiology · 2025Review
- Serovar-specific genomic features ofFrontiers in molecular biosciences · 2025Article
- New Genetic Variants ofJournal of tropical medicine · 2022Article
- 12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka.PLoS neglected tropical diseases · 2021Article
- Unique Features of Tandem Repeats in Bacteria.Journal of bacteriology · 2020Article
- Article
- Genus-wide Leptospira core genome multilocus sequence typing for strain taxonomy and global surveillance.PLoS neglected tropical diseases · 2019Article
- Article
- Review
- Genomic Comparison Among Global Isolates ofFrontiers in cellular and infection microbiology · 2018Article
- Genomic Variability among Field Isolates and Laboratory-Adapted Strains ofInternational journal of microbiology · 2018Article
- Isolation and characterization ofJMM case reports · 2017Article
- Virulence of the zoonotic agent of leptospirosis: still terra incognita?Nature reviews. Microbiology · 2017Review
- A Universal Vaccine against Leptospirosis: Are We Going in the Right Direction?Frontiers in immunology · 2017Article
- Genomic Analysis of a New Serovar ofFrontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genome of a laboratory-adapted strain of Leptospira interrogans serovar Hardjo was sequenced and analyzed. Comparison of the sequenced genome with that recently published for a field isolate of the same serovar revealed relatively high sequence conservation at the nucleotide level, despite the different biological background of both samples. Conversely, comparison of both serovar Hardjo genomes with those of L. borgpetersenii serovar Hardjo showed extensive differences between the corresponding chromosomes, except for the region occupied by their rfb loci. Additionally, comparison of the serovar Hardjo genomes with those of different L. interrogans serovars allowed us to detect several genomic features that may confer an adaptive advantage to L. interrogans serovar Hardjo, including a possible integrated plasmid and an additional copy of a cluster encoding a membrane transport system known to be involved in drug resistance. A phylogenomic strategy was used to better understand the evolutionary position of the Hardjo serovar among L. interrogans serovars and other Leptospira species. The proposed phylogeny supports the hypothesis that the presence of similar rfb loci in two different species may be the result of a lateral gene transfer event.
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