Evidence map›Paper›PMID 27442009›Full record

ArticleAIDS care2017

The association between substance use and sub-optimal HIV treatment engagement among HIV-infected female sex workers in Lilongwe, Malawi.

Kathryn E Lancaster, Thandie Lungu, Pearson Mmodzi, Mina C Hosseinipour, Katy Chadwick, Kimberly A Powers, Brian W Pence, Vivian F Go, Irving F Hoffman, William C Miller

Open access · greenAbstract read
In one paragraph

Article in AIDS care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
12.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Kathryn E Lancastera Department of Epidemiology , Gillings School of Global Public Health, The University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.
Thandie Lunguc UNC Project Malawi, University of North Carolina at Chapel Hill , Lilongwe , Malawi.
Pearson Mmodzic UNC Project Malawi, University of North Carolina at Chapel Hill , Lilongwe , Malawi.
Mina C Hosseinipourb Division of Infectious Diseases , School of Medicine, University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.
Katy Chadwickd Theatre for a Change , Lilongwe , Malawi.
Kimberly A Powersa Department of Epidemiology , Gillings School of Global Public Health, The University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.
Brian W Pencea Department of Epidemiology , Gillings School of Global Public Health, The University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.
Vivian F Goe Department of Health Behavior , Gillings School of Global Public Health, The University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.
Irving F Hoffmanb Division of Infectious Diseases , School of Medicine, University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.
William C Millera Department of Epidemiology , Gillings School of Global Public Health, The University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.
University of North Carolina at Chapel Hill · USUniversity of Malawi · MW

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Training in Sexually Transmitted Infections and HIVT32AI007001 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SENA-SOBERANO, ARLENE C. · 1985 to 2025
$10.9M
Fogarty Global Health Fellows Coordinating CenterR25TW009340 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHI, BENJAMIN H. · 2012 to 2016
$6.9M
North Carolina Translational & Clinical Sciences Institute (NC TraCS)KL2TR001109 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$5.7M
FIC NIH HHS R25 TW009340NCATS NIH HHS KL2 TR001109NIAID NIH HHS P30 AI050410NIAID NIH HHS T32 AI007001
6 · The paper itself

Abstract

Female sex workers (FSW) have a high prevalence of substance use and HIV, but the impact of substance use on HIV treatment engagement is not well established. We evaluated the association between alcohol and marijuana use and sub-optimal HIV treatment engagement outcomes among HIV-infected FSW in Lilongwe, Malawi. We enroled FSW using venue-based recruitment into a cross-sectional evaluation assessing substance use and HIV treatment engagement. Seropositive FSW, identified through HIV rapid testing, received rapid CD4 count and viral load testing. We used Poisson regression with robust variance estimates to ascertain associations of alcohol and marijuana use with sub-optimal HIV treatment outcomes: (1) lack of ART use among previously diagnosed, ART-eligible FSW and (2) viral nonsuppression among FSW on ART. Of previously diagnosed, ART-eligible FSW (n = 96), 29% were not using ART. Patterns of hazardous drinking were identified in 30%, harmful drinking in 10%, and alcohol dependence in 12%. ART-eligible FSW with harmful drinking or alcohol dependency were 1.9 (95% CI: 1.0, 3.8) times as likely to not use ART compared to FSW without harmful or dependent drinking. Among those on ART, 14% were virally nonsuppressed. The prevalence ratio for viral nonsuppression was 2.0 (95% CI: 0.6, 6.5) for harmful drinkers and alcohol-dependent FSW. Over 30% of ART-eligible FSW reported using marijuana. Marijuana-using FSW were 1.9 (95% CI: 0.8, 4.6) times as likely to not use ART compared to FSW who were not using marijuana. Given the high prevalence of alcohol use and its association with lack of ART use, ART uptake and alcohol reduction strategies should be tailored for alcohol-using FSW in Malawi.

Indexed as

Drug MonitoringAdolescentAdultAlcoholismAnti-HIV AgentsCross-Sectional StudiesFemaleHIV SeropositivityHumansMalawiMaleMarijuana AbusePrevalenceSex WorkersTreatment OutcomeYoung AdultAnti-HIV Agentsalcoholantiretroviral therapyFSWmarijuanaviral suppression

Identifiers

PMID27442009
PMCPMC5138102
OpenAlexW2501937365

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.