Observational studyPloS one2016
Conducting Precision Medicine Research with African Americans.
Observational study in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The role of race and ethnicity in views toward and participation in genetic studies and precision medicine research in the United States: A systematic review of qualitative and quantitative studies.Molecular genetics & genomic medicine · 2020Pooled it
- Racial and ethnic differences in knowledge and attitudes about genetic testing in the US: Systematic review.Journal of genetic counseling · 2019Pooled it
- Article
- Key contextual factors involved with participation in medical and genomic screening and research for African American and White Americans: a qualitative inquiry.Journal of community genetics · 2024Article
- Development of a Hereditary Breast and Ovarian Cancer and Genetics Curriculum for Community Health Workers: KEEP IT (Keeping Each other Engaged Program via IT) Community Health Worker Training.Journal of cancer education : the official journal of the American Association for Cancer Education · 2024Article
- Review of genetic and pharmacogenetic differences in cytotoxic and targeted therapies for pancreatic cancer in African Americans.Journal of the National Medical Association · 2023Review
- Understanding men's beliefs and concerns about linking health data in the context of precision medicine.Journal of clinical and translational science · 2023Article
- Equity in Genomic Medicine.Annual review of genomics and human genetics · 2022Review
- Knowledge and Attitudes about Privacy and Secondary Data Use among African-Americans Using Direct-to-Consumer Genetic Testing.Public health genomics · 2022Article
- Testing a deliberative democracy method with citizens of African ancestry to weigh pros and cons of targeted screening for hereditary breast and ovarian cancer risk.Frontiers in public health · 2022Article
- Opportunities to Improve Women's Health: Engaging Racial/Ethnic Diverse Women to Provide Biospecimens for Research.Journal of women's health (2002) · 2021Article
- Engagement and return of results preferences among a primarily African American genomic sequencing research cohort.American journal of human genetics · 2021Article
- Structural Racism in the COVID-19 Pandemic: Moving Forward.The American journal of bioethics : AJOB · 2021Article
- Article
- Examining access to care in clinical genomic research and medicine: Experiences from the CSER Consortium.Journal of clinical and translational science · 2021Article
- Understanding Participation in Genetic Research Among Patients With Multiple Sclerosis: The Influences of Ethnicity, Gender, Education, and Age.Frontiers in genetics · 2020Article
- In Different Voices: The Views of People with Disabilities about Return of Results from Precision Medicine Research.Public health genomics · 2020Article
- Attitudes and experiences regarding genetic research among persons of African descent.Journal of community genetics · 2020Article
- Including the blind community in precision medicine research: findings from a national survey and recommendations.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Article
- Disability inclusion in precision medicine research: a first national survey.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
importancePrecision medicine is an approach to detecting, treating, and managing disease that is based on individual variation in genetic, environmental, and lifestyle factors. Precision medicine is expected to reduce health disparities, but this will be possible only if studies have adequate representation of racial minorities.
objectiveIt is critical to anticipate the rates at which individuals from diverse populations are likely to participate in precision medicine studies as research initiatives are being developed. We evaluated the likelihood of participating in a clinical study for precision medicine. DESIGN, SETTING,
participantsObservational study conducted between October 2010 and February 2011 in a national sample of African Americans.
main outcome measureIntentions to participate in a government sponsored study that involves providing a biospecimen and generates data that could be shared with other researchers to conduct future studies.
resultsOne third of respondents would participate in a clinical study for precision medicine. Only gender had a significant independent association with participation intentions. Men had a 1.86 (95% CI = 1.11, 3.12, p = 0.02) increased likelihood of participating in a precision medicine study compared to women in the model that included overall barriers and facilitators. In the model with specific participation barriers, distrust was associated with a reduced likelihood of participating in the research described in the vignette (OR = 0.57, 95% CI = 0.34, 0.96, p = 0.04). CONCLUSION AND RELEVANCE: African Americans may have low enrollment in PMI research. As PMI research is implemented, extensive efforts will be needed to ensure adequate representation. Additional research is needed to identify optimal ways of ethically describing precision medicine studies to ensure sufficient recruitment of racial minorities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.