ArticlePLoS biology2016
Spatial Embedding and Wiring Cost Constrain the Functional Layout of the Cortical Network of Rodents and Primates.
Article in PLoS biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
116 citing papers in PubMed.
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- Modeling the influences of non-local connectomic projections on geometrically constrained cortical dynamics.PLoS computational biology · 2026Article
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- Independence and coherence in temporal sequence computation across the fronto-parietal network.Nature communications · 2026Article
- Projection-specific intersectional optogenetics for precise excitation and inhibition in the marmoset brain.Cell reports methods · 2026Article
- 'Backpropagation and the brain' realized in cortical error neuron microcircuits.PLoS computational biology · 2026Article
- From comparative connectomics to large-scale working memory modeling in macaque and marmoset.Cell reports · 2026Article
- On the topical issue of assisted dying: the insurmountable challenges of human existence, and the right to exit.Frontiers in public health · 2026Article
- A feasible probability and graph model for memory engrams.Frontiers in computational neuroscience · 2026Article
- Structured interconnectivity optimizes neural geometry for balancing specificity and generalization in object recognition.Communications biology · 2025Article
- Routing of task-relevant information in mouse PPC during continuous visuomotor control.bioRxiv : the preprint server for biology · 2025Article
- Leveraging network motifs to improve artificial neural networks.Nature communications · 2025Article
- A hierarchy of time constants and reliable signal propagation in the marmoset cerebral cortex.Nature communications · 2025Article
- Building the connectome of a small brain with a simple stochastic developmental generative model.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A doubly stochastic renewal framework for partitioning spiking variability.Nature communications · 2025Article
- Geometric constraints on the architecture of mammalian cortical connectomes.bioRxiv : the preprint server for biology · 2025Article
- From comparative connectomics to large-scale working memory modeling in macaque and marmoset.bioRxiv : the preprint server for biology · 2025Article
- Benchmarking methods for mapping functional connectivity in the brain.Nature methods · 2025Article
- Inferring Neural Communication Dynamics from Field Potentials Using Graph Diffusion Autoregression.bioRxiv : the preprint server for biology · 2025Article
56 more citing papers are in PubMed but not listed here.
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10 authors.
Funding
Abstract
Mammals show a wide range of brain sizes, reflecting adaptation to diverse habitats. Comparing interareal cortical networks across brains of different sizes and mammalian orders provides robust information on evolutionarily preserved features and species-specific processing modalities. However, these networks are spatially embedded, directed, and weighted, making comparisons challenging. Using tract tracing data from macaque and mouse, we show the existence of a general organizational principle based on an exponential distance rule (EDR) and cortical geometry, enabling network comparisons within the same model framework. These comparisons reveal the existence of network invariants between mouse and macaque, exemplified in graph motif profiles and connection similarity indices, but also significant differences, such as fractionally smaller and much weaker long-distance connections in the macaque than in mouse. The latter lends credence to the prediction that long-distance cortico-cortical connections could be very weak in the much-expanded human cortex, implying an increased susceptibility to disconnection syndromes such as Alzheimer disease and schizophrenia. Finally, our data from tracer experiments involving only gray matter connections in the primary visual areas of both species show that an EDR holds at local scales as well (within 1.5 mm), supporting the hypothesis that it is a universally valid property across all scales and, possibly, across the mammalian class.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.