Evidence map›Paper›PMID 27441589›Full record

ArticleApplied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme2016

Short-term exercise training improves flow-mediated dilation and circulating angiogenic cell number in older sedentary adults.

Rian Q Landers-Ramos, Kelsey J Corrigan, Lisa M Guth, Christine N Altom, Espen E Spangenburg, Steven J Prior, James M Hagberg

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 33 citations in OpenAlex.

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  20. Exercise and Cardiovascular Progenitor Cells.Comprehensive Physiology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Rian Q Landers-Ramosa Department of Kinesiology, University of Maryland, College Park, MD 20742-2611, USA.
Kelsey J Corrigana Department of Kinesiology, University of Maryland, College Park, MD 20742-2611, USA.
Lisa M Gutha Department of Kinesiology, University of Maryland, College Park, MD 20742-2611, USA.
Christine N Altoma Department of Kinesiology, University of Maryland, College Park, MD 20742-2611, USA.
Espen E Spangenburga Department of Kinesiology, University of Maryland, College Park, MD 20742-2611, USA.
Steven J Priorb University of Maryland School of Medicine and Baltimore VA GRECC, Baltimore, MD 21201, USA.
James M Hagberga Department of Kinesiology, University of Maryland, College Park, MD 20742-2611, USA.
University of Maryland, College Park · US

Funding

University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Stephen L. Seliger · 2006 to 2026
$28.9M
Vascular Biology Training ProgramT32HL007698 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Rosemary A Kozar, Dudley K. Strickland · 1991 to 2026
$8.7M
PREDOCTORAL TRAINING IN EXERCISE PHYSIOLOGY AND AGINGT32AG000268 · NIA · UNIV OF MARYLAND, COLLEGE PARK · PI HAGBERG, JAMES M · 1999 to 2014
$2.5M
Effects of Aerobic Exerise on EPCs and Vascular Dysfunction in Aging and T2DMK23AG040775 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI PRIOR, STEVEN J · 2012 to 2014
$532k
Translational Studies of Endothelial Progenitor Cells as a Novel Cardiovascular DR21HL098810 · NHLBI · UNIV OF MARYLAND, COLLEGE PARK · PI HAGBERG, JAMES M · 2011 to 2012
$391k
NHLBI NIH HHS R21 HL098810NHLBI NIH HHS T32 HL007698NIA NIH HHS K23 AG040775NIA NIH HHS P30 AG028747NIA NIH HHS T32 AG000268
6 · The paper itself

Abstract

Cardiovascular disease risk increases with age due, in part, to impaired endothelial function and decreased circulating angiogenic cell (CAC) number and function. We sought to determine if 10 days of aerobic exercise training improves endothelial function, CAC number, and intracellular redox balance in older sedentary adults. Eleven healthy subjects (4 men, 7 women), 61 ± 2 years of age participated in 60 min of aerobic exercise at 70% maximal oxygen consumption for 10 consecutive days while maintaining body weight. Before and after training, endothelial function was measured as flow-mediated dilation of the brachial artery and fasting blood was drawn to enumerate 3 CAC subtypes. Intracellular reactive oxygen species (ROS) and nitric oxide (NO) in CD34+ CACs were measured using fluorescent probes and reinforced via real-time quantitative polymerase chain reaction. Flow-mediated dilation improved significantly following training (10% ± 1.3% before vs. 16% ± 1.4% after training; P < 0.05). Likewise, CD34+/KDR+ number increased 104% and KDR+ number increased 151% (P < 0.05 for both), although CD34+ number was not significantly altered (P > 0.05). Intracellular NO and ROS levels in CD34+ CACs were not different after training (P > 0.05 for both). Messenger RNA expression of SOD1, endothelial nitric oxide synthase, and NADPH oxidase 2 and neutrophil cytosolic factor 1 in CD34+ CACs was not significantly altered with training (P > 0.05). In conclusion, 10 consecutive days of aerobic exercise increased flow-mediated dilation and CAC number in older, previously sedentary adults, but did not affect intracellular redox balance in CD34+ CACs. Overall, these data indicate that even short-term aerobic exercise training can have a significant impact on cardiovascular disease risk factors.

Indexed as

Sedentary BehaviorAbsorptiometry, PhotonBlood PressureBody CompositionBody Mass IndexBrachial ArteryCell CountCholesterol, HDLCholesterol, LDLDilatationEndothelial CellsEndothelium, VascularExerciseFemaleHumansMaleCholesterol, HDLCholesterol, LDLCYBB protein, humanMembrane GlycoproteinsNADPH Oxidase 2NADPH Oxidasesneutrophil cytosolic factor 1Nitric OxideNitric Oxide Synthase Type IIINOS3 protein, humanReactive Oxygen SpeciesRNA, MessengerSOD1 protein, humanSuperoxide Dismutase-1Triglyceridesaerobic exercise trainingcellules angiogéniques circulantescirculating angiogenic cellsendothelial functionentraînement physique aérobieexercice physique à court termefonction endothélialeshort-term exercise

Identifiers

PMID27441589
PMCPMC5456122
OpenAlexW2332641398

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.