Evidence map›Paper›PMID 27441568›Full record

ArticlePloS one2016

Assessment of Risk and Sero-Prevalence of Helicobacter pylori Colonization among Remote Orang Asli Tribes in Peninsula Malaysia.

Kavitha Thevakumar, Josephine Rebecca Chandren, Guillermo Ignacio Perez-Perez, Eng Guan Chua, Lay Kek Teh, Mohd Zaki Salleh, Jin Ai Mary Anne Tan, Alex Hwong Ruey Leow, Khean Lee Goh, Alfred Chin Yen Tay and 4 more

Abstract read
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kavitha ThevakumarDepartment of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia.
Josephine Rebecca ChandrenDepartment of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Guillermo Ignacio Perez-PerezDepartments of Medicine and Microbiology, New York University School of Medicine and VA Medical Center, New York, United States of America.
Eng Guan ChuaThe Marshall Centre for Infectious Diseases Research and Training, School of Pathology and Laboratory Medicine (M502), University of Western Australia, Perth, Australia.
Lay Kek TehIntegrative Pharmacogenomics Institute, Universiti Teknologi MARA, Selangor, Malaysia.
Mohd Zaki SallehIntegrative Pharmacogenomics Institute, Universiti Teknologi MARA, Selangor, Malaysia.
Jin Ai Mary Anne TanDepartment of Biomedical Science, University of Malaya, Kuala Lumpur, Malaysia.
Alex Hwong Ruey LeowDepartment of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Khean Lee GohDepartment of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Alfred Chin Yen TayThe Marshall Centre for Infectious Diseases Research and Training, School of Pathology and Laboratory Medicine (M502), University of Western Australia, Perth, Australia.
Barry J MarshallThe Marshall Centre for Infectious Diseases Research and Training, School of Pathology and Laboratory Medicine (M502), University of Western Australia, Perth, Australia.
Jamuna VadiveluDepartment of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia.
Mun Fai LokeDepartment of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia.
Li Ping WongDepartment of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The epidemiology of Helicobacter pylori (H. pylori) infection is related to human poverty with marked differences between developing and developed countries. Socioeconomic factors and living standards are the main determinants of the age-dependent acquisition rate of H. pylori, and consequently its prevalence. The aim of this study was to assess the risk and sero-prevalence of H. pylori colonization among Orang Asli in Peninsula Malaysia. This cross-sectional study was conducted on Orang Asli subjects in seven isolated settlements spanning across all three major tribes (Negrito, Proto Malay and Senoi) in Malaysia. Socio-demographic characteristics of the subjects were obtained through interview. Subjects were tested for H. pylori colonization based on CagA and whole cell (WC) antigen serological assays. A total of 275 subjects participated in this study. Among these subjects, 115 (44.7%) were H. pylori sero-positive with highest sero-prevalence among Negrito (65.7%). Among subjects who were H. pylori sero-positive, CagA sero positivity was also significantly higher among Negrito. The highest proportion of respondents reported to be H. pylori sero-positive was from age group 30 years old and below (57.9%), males (56.2%), Negrito (48.6%) and live in bamboo house (92.3%). The highest proportion of respondents reported to be CagA sero-positive was from age group 30 years old and below (41.4%), males (35.6%) and Negrito (48.6%). The results of this study demonstrate that H. pylori colonization can be related to age, gender, tribes and house materials and CagA sero-positive stain closely associated with age, gender and tribes.

Indexed as

Asian PeopleHelicobacter pyloriAdultFemaleGeographyHelicobacter InfectionsHumansLife StyleMalaysiaMaleMiddle AgedPhenotypeRisk AssessmentSeroepidemiologic StudiesSocioeconomic FactorsYoung Adult

Identifiers

PMID27441568
PMCPMC4956210

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.