ArticleeLife2016
Calcium imaging with genetically encoded indicators in behaving primates.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Prefrontal cortex interneurons and their contributions to attention, working memory, and adaptive behavior.Progress in neurobiology · 2026Review
- Fast neural population dynamics in primate V1 captured by a genetically-encoded voltage indicator.Research square · 2025Article
- Large-scale calcium imaging reveals a systematic V4 map for encoding natural scenes.Nature communications · 2024Article
- Disparate nonlinear neural dynamics measured with different techniques in macaque and human V1.Scientific reports · 2024Article
- Mesoscopic calcium imaging in a head-unrestrained male non-human primate using a lensless microscope.Nature communications · 2024Article
- Genetically encoded fluorescent sensors for imaging neuronal dynamics in vivo.Journal of neurochemistry · 2023Review
- Review
- Head-mounted optical imaging and optogenetic stimulation system for use in behaving primates.Cell reports methods · 2022Article
- Fluorescence Imaging of Neural Activity, Neurochemical Dynamics, and Drug-Specific Receptor Conformation with Genetically Encoded Sensors.Annual review of neuroscience · 2022Review
- Review
- Review
- Similar neural and perceptual masking effects of low-power optogenetic stimulation in primate V1.eLife · 2022Article
- Two-photon calcium imaging of neuronal activity.Nature reviews. Methods primers · 2022Article
- WhatFrontiers in neural circuits · 2022Review
- Miniature microscopes for manipulating and recording in vivo brain activity.Microscopy (Oxford, England) · 2021Article
- Microendoscopic calcium imaging of the primary visual cortex of behaving macaques.Scientific reports · 2021Article
- Combining brain perturbation and neuroimaging in non-human primates.NeuroImage · 2021Review
- Transduction catalysis: Doxorubicin amplifies rAAV-mediated gene expression in the cortex of higher-order vertebrates.iScience · 2021Article
- Dendritic calcium signals in rhesus macaque motor cortex drive an optical brain-computer interface.Nature communications · 2021Article
- Head-mounted microendoscopic calcium imaging in dorsal premotor cortex of behaving rhesus macaque.Cell reports · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Understanding the neural basis of behaviour requires studying brain activity in behaving subjects using complementary techniques that measure neural responses at multiple spatial scales, and developing computational tools for understanding the mapping between these measurements. Here we report the first results of widefield imaging of genetically encoded calcium indicator (GCaMP6f) signals from V1 of behaving macaques. This technique provides a robust readout of visual population responses at the columnar scale over multiple mm(2) and over several months. To determine the quantitative relation between the widefield GCaMP signals and the locally pooled spiking activity, we developed a computational model that sums the responses of V1 neurons characterized by prior single unit measurements. The measured tuning properties of the GCaMP signals to stimulus contrast, orientation and spatial position closely match the predictions of the model, suggesting that widefield GCaMP signals are linearly related to the summed local spiking activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.