ArticleeLife2016
Dopaminergic neurons write and update memories with cell-type-specific rules.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 149 papers.
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Who cites it
149 citing papers in PubMed, 340 citations in OpenAlex.
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- Creating true and false memories from forgotten information in Drosophila.Nature neuroscience · 2026Article
- A highly sensitive genetically encoded red cAMP sensor for multiplex imaging in vivo.Nature communications · 2026Article
- Selective octopaminergic tuning of mushroom body circuits during memory formation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Aberrant dopaminergic activity during consolidation causes age-related memory generalization in Drosophila.PLoS biology · 2026Article
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- A pair of interneurons that confer positive real-time valence to sweet sensation in Drosophila.Current biology : CB · 2026Article
- Re-exposure to reward re-evaluates related memories.Current biology : CB · 2026Article
- Octopamine instructs head direction plasticity.bioRxiv : the preprint server for biology · 2025Article
- Role of Long Non-Coding RNAs in Food Wanting ofInsects · 2025Article
- Review
- Dual roles ofiScience · 2025Article
- From perception to valence: a pair of interneurons that assign positive valence to sweet sensation inbioRxiv : the preprint server for biology · 2025Article
- Ascending nociceptive pathways drive rapid escape and sustained avoidance in adultbioRxiv : the preprint server for biology · 2025Article
- Entirely synthetic memory inception via dual optogenetic activation of sensory and dopaminergic neurons.iScience · 2025Article
- Article
- Ant visual route navigation: How the fine details of behaviour promote successful route performance and convergence.PLoS computational biology · 2025Article
- Sensitive dLight3 for imaging broad-spectrum dopamine events across brain regions.Research square · 2025Article
- A distinct neural ensemble to integrate contradictory information and form long-term memory inScience advances · 2025Article
89 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Associative learning is thought to involve parallel and distributed mechanisms of memory formation and storage. In Drosophila, the mushroom body (MB) is the major site of associative odor memory formation. Previously we described the anatomy of the adult MB and defined 20 types of dopaminergic neurons (DANs) that each innervate distinct MB compartments (Aso et al., 2014a, 2014b). Here we compare the properties of memories formed by optogenetic activation of individual DAN cell types. We found extensive differences in training requirements for memory formation, decay dynamics, storage capacity and flexibility to learn new associations. Even a single DAN cell type can either write or reduce an aversive memory, or write an appetitive memory, depending on when it is activated relative to odor delivery. Our results show that different learning rules are executed in seemingly parallel memory systems, providing multiple distinct circuit-based strategies to predict future events from past experiences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.