ArticleHeliyon2016
Engineering tissues with a perfusable vessel-like network using endothelialized alginate hydrogel fiber and spheroid-enclosing microcapsules.
Article in Heliyon, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 30 citations in OpenAlex.
- Biomimetic hydrogel micro-/nanofibers forBioactive materials · 2026Review
- Technique for Rapidly Forming Networks of Microvessel-Like Structures.Tissue engineering. Part C, Methods · 2024Article
- Technique for rapidly forming networks of microvessel-like structures.bioRxiv : the preprint server for biology · 2024Article
- Review
- Alginate-based complex fibers with the Janus morphology for controlled release of co-delivered drugs.Asian journal of pharmaceutical sciences · 2021Article
- Fiber-based platform for synchronous imaging of endogenous and exogenous fluorescence of biological tissue.Optics letters · 2019Article
- Formation of pressurizable hydrogel-based vascular tissue models by selective gelation in composite PDMS channels.RSC advances · 2019Article
- Fiber-based fluorescence lifetime imaging of recellularization processes on vascular tissue constructs.Journal of biophotonics · 2018Article
- Adaptive Multifunctional Supramolecular Assemblies of Glycopeptides Rapidly Enable Morphogenesis.Biochemistry · 2018Article
- Vascularized microfluidic organ-chips for drug screening, disease models and tissue engineering.Current opinion in biotechnology · 2018Review
- Formation of Branched and Chained Alginate Microfibers Using Theta-Glass Capillaries.Micromachines · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Development of the technique for constructing an internal perfusable vascular network is a challenging issue in fabrication of dense three-dimensional tissues in vitro. Here, we report a method for realizing it. We assembled small tissue (about 200 μm in diameter)-enclosing hydrogel microcapsules and a single hydrogel fiber, both covered with human vascular endothelial cells in a collagen gel. The microcapsules and fiber were made from alginate and gelatin derivatives, and had cell adhesive surfaces. The endothelial cells on the hydrogel constructs sprouted and spontaneously formed a network connecting the hydrogel constructs with each other in the collagen gel. Perfusable vascular network-like structure formation after degrading the alginate-based hydrogel constructs by alginate lyase was confirmed by introducing solution containing tracer particles of about 3 μm in diameter into the lumen templated by the alginate hydrogel fiber. The introduced solution flowed into the spontaneously formed capillary branches and passed around the individual spherical tissues.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.