Evidence map›Paper›PMID 27441227›Full record

ArticleHeliyon2015

Comprehensive characterization of evolutionary conserved breakpoints in four New World Monkey karyotypes compared to Chlorocebus aethiops and Homo sapiens.

Xiaobo Fan, Weerayuth Supiwong, Anja Weise, Kristin Mrasek, Nadezda Kosyakova, Alongkoad Tanomtong, Krit Pinthong, Vladimir A Trifonov, Marcelo de Bello Cioffi, Pierre Grothmann and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. From Human Cytogenetics to Human Chromosomics.International journal of molecular sciences · 2019
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 4 countries.

Xiaobo FanJena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Kollegiengasse 10, D-07743 Jena, Germany.
Weerayuth SupiwongDepartment of Biology Faculty of Science, KhonKaen University, 123 Moo 16 Mittapap Rd., Muang District, KhonKaen 40002, Thailand.
Anja WeiseJena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Kollegiengasse 10, D-07743 Jena, Germany.
Kristin MrasekJena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Kollegiengasse 10, D-07743 Jena, Germany.
Nadezda KosyakovaJena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Kollegiengasse 10, D-07743 Jena, Germany.
Alongkoad TanomtongDepartment of Biology Faculty of Science, KhonKaen University, 123 Moo 16 Mittapap Rd., Muang District, KhonKaen 40002, Thailand.
Krit PinthongDepartment of Biology Faculty of Science, KhonKaen University, 123 Moo 16 Mittapap Rd., Muang District, KhonKaen 40002, Thailand.
Vladimir A TrifonovInstitute of Molecular and Cellular Biology SB RAS, Novosibirsk, Russia.
Marcelo de Bello CioffiDepartamento de Genética e Evolução, Universidade Federal de São Carlos, São Carlos, SP, Brazil.
Pierre GrothmannSerengeti-Park Hodenhagen GmbH, Am Safaripark 1, 29693, Hodenhagen, Germany.
Thomas LiehrJena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Kollegiengasse 10, D-07743 Jena, Germany.
Edivaldo H C de OliveiraFaculdade de Ciências Naturais, ICEN, Universidade Federal do Pará, Campus Universitário do Guamá, 66075-110 Belém-PA, Brazil.
Jena University Hospital · DEKhon Kaen University · THFriedrich Schiller University Jena · DEInstitute of Molecular and Cell Biology · RUUniversidade Federal de São Carlos · BRUniversidade Federal do Pará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Comparative cytogenetic analysis in New World Monkeys (NWMs) using human multicolor banding (MCB) probe sets were not previously done. Here we report on an MCB based FISH-banding study complemented with selected locus-specific and heterochromatin specific probes in four NWMs and one Old World Monkey (OWM) species, i.e. in Alouatta caraya (ACA), Callithrix jacchus (CJA), Cebus apella (CAP), Saimiri sciureus (SSC), and Chlorocebus aethiops (CAE), respectively. 107 individual evolutionary conserved breakpoints (ECBs) among those species were identified and compared with those of other species in previous reports. Especially for chromosomal regions being syntenic to human chromosomes 6, 8, 9, 10, 11, 12 and 16 previously cryptic rearrangements could be observed. 50.4% (54/107) NWM-ECBs were colocalized with those of OWMs, 62.6% (62/99) NWM-ECBs were related with those of Hylobates lar (HLA) and 66.3% (71/107) NWM-ECBs corresponded with those known from other mammalians. Furthermore, human fragile sites were aligned with the ECBs found in the five studied species and interestingly 66.3% ECBs colocalized with those fragile sites (FS). Overall, this study presents detailed chromosomal maps of one OWM and four NWM species. This data will be helpful to further investigation on chromosome evolution in NWM and hominoids in general and is prerequisite for correct interpretation of future sequencing based genomic studies in those species.

Indexed as

ACA, Alouatta carayaAtelidaeBACs, bacterial artificial chromosomesCAE, Chlorocebus aethiopsCAP, Cebus apellaCebidaeCJA, Callithrix jacchusECBs, evolutionary conserved breakpointsEC, evolutionary conservedEvolutionary conserved breakpointsEvolutionary geneticsFISH, fluorescence in situ hybridizationFragile sitesFS, fragile siteGeneticsHCM, heterochromatin mixHLA, Hylobates larHSA, Homo sapiensHSBs, homologous syntenic blocksMCB, multicolor bandingMulticolor bandingNew World MonkeysNGS, Next-generation sequencingNOR, nucleolus organizer regionNWMs, New World MonkeysOld World MonkeysOWMs, Old World MonkeysSSC, Saimiri sciureussubCTM, sub-centromere/subtelomere-specific multicolor (FISH)wcp, whole human chromosome painting

Identifiers

PMID27441227
PMCPMC4945616
OpenAlexW2173752745

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.