Evidence map›Paper›PMID 27441213›Full record

ArticleHeliyon2015

BVD-2 outbreak leads to high losses in cattle farms in Western Germany.

Jörn Gethmann, Timo Homeier, Mark Holsteg, Horst Schirrmeier, Michael Saßerath, Bernd Hoffmann, Martin Beer, Franz J Conraths

Open access · goldAbstract read
In one paragraph

Article in Heliyon, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
9.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Identification of Genomic Instability in Cows Infected with BVD Virus.Animals : an open access journal from MDPI · 2023
    Article
  3. Article
  4. The contribution of bovines to human health against viral infections.Environmental science and pollution research international · 2021
    Review
  5. Article
  6. Epidemiology ofFrontiers in veterinary science · 2021
    Review
  7. Epidemiology of Bovine Pestiviruses Circulating in Italy.Frontiers in veterinary science · 2021
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Persistent BVD virus infections in offspring from imported heifers.Tropical animal health and production · 2019
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jörn GethmannFriedrich-Loeffler-Institut, Institute of Epidemiology, Südufer 10, 17493 Greifswald - Insel Riems, Germany.
Timo HomeierFriedrich-Loeffler-Institut, Institute of Epidemiology, Südufer 10, 17493 Greifswald - Insel Riems, Germany.
Mark HolstegLandwirtschaftskammer Nordrhein-Westfalen, Bovine Health Service, Siebengebirgsstraße 200, 53229 Bonn, Germany.
Horst SchirrmeierFriedrich-Loeffler-Institut, Institute of Diagnostic Virology, Südufer 10, 17493 Greifswald - Insel Riems, Germany.
Michael SaßerathChemisches und Veterinäruntersuchungsamt Rhein-Ruhr-Wupper, Deutscher Ring 100, 47798 Krefeld, Germany.
Bernd HoffmannFriedrich-Loeffler-Institut, Institute of Diagnostic Virology, Südufer 10, 17493 Greifswald - Insel Riems, Germany.
Martin BeerFriedrich-Loeffler-Institut, Institute of Diagnostic Virology, Südufer 10, 17493 Greifswald - Insel Riems, Germany.
Franz J ConrathsFriedrich-Loeffler-Institut, Institute of Epidemiology, Südufer 10, 17493 Greifswald - Insel Riems, Germany.
Friedrich-Loeffler-Institut · DELandwirtschaftskammer Nordrhein-Westfalen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In November 2012, a dairy farmer in the district Kleve first observed a reduction in milk yield, respiratory symptoms, nasal discharge, fever, sporadic diarrhoea and sudden deaths in dairy cows and calves. In the following months, further farms were found infected with cattle showing similar clinical signs. An epidemiological investigation was carried out to identify the source of infection, the date of introduction, potential transmission pathways and to analyse the extent of the epidemic. Furthermore, laboratory analyses were conducted to characterise the causative agent. BVDV had been diagnosed in the index herd in December 2012, but due to the atypical clinical picture, the virus was not immediately recognised as the causative agent. Further laboratory analysis showed that this outbreak and subsequent infections in the area were caused by a BVD type 2c virus with a characteristic genome insertion, which seems to be associated with the occurrence of severe clinical symptoms in infected cattle. Epidemiological investigations showed that the probable date of introduction was in mid-October 2012. The high risk period was estimated as three months. A total of 21 affected farms with 5325 cattle were identified in two German Federal States. The virus was mainly transmitted by person contacts, but also by cattle trade and vehicles. The case-fatality rate was up to 60% and mortality in outbreak farms varied between 2.3 and 29.5%. The competent veterinary authorities imposed trade restrictions on affected farms. All persons who had been in contact with affected animals were advised to increase biosecurity measures (e.g. using farm-owned or disposable protective clothing). In some farms, affected animals were vaccinated against BVD to reduce clinical signs as an "emergency measure". These measures stopped the further spread of the disease.

Indexed as

Bovine viral diarrheaBVDV-2EpidemiologyGermanyOutbreakPestivirus

Identifiers

PMID27441213
PMCPMC4939757
OpenAlexW1690503532

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.