Evidence map›Paper›PMID 27440969›Full record

ArticleEthnicity & disease2016

Age, Race and Cardiovascular Outcomes in African American Veterans.

Keith C Norris, George A Mensah, L Ebony Boulware, Jun L Lu, Jennie Z Ma, Elani Streja, Miklos Z Molnar, Kamyar Kalantar-Zadeh, Csaba P Kovesdy

Open access · hybridAbstract read
In one paragraph

Article in Ethnicity & disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
7.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Epidemiology of chronic kidney disease: an update 2022.Kidney international supplements · 2022 · on this map
    Review
  4. Article
  5. Review
  6. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Keith C NorrisDavid Geffen School of Medicine; University of California, Los Angeles.
George A MensahNational Heart, Lung, and Blood Institute, National Institutes of Health.
L Ebony BoulwareDepartment of Medicine, Duke University.
Jun L LuUniversity of Tennessee Heath Science Center.
Jennie Z MaUniversity of Virginia.
Elani StrejaUniversity of California, Irvine.
Miklos Z MolnarUniversity of Tennessee Heath Science Center.
Kamyar Kalantar-ZadehUniversity of California, Irvine.
Csaba P KovesdyUniversity of Tennessee Heath Science Center; Memphis VA Medical Center.
University of California, Irvine · USUniversity of Tennessee Health Science Center · USDuke University · USMemphis VA Medical Center · USNational Heart Lung and Blood Institute · USUniversity of California, Los Angeles · USUniversity of Virginia · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
The Center for Health Improvement of Minority ElderlyP30AG021684 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CATHERINE A SARKISIAN · 2002 to 2026
$19.7M
TRAINING COREP20MD000182 · NIMHD · CHARLES R. DREW UNIVERSITY OF MED &SCI · PI CUNNINGHAM, WILLIAM EMERY, SHAPIRO, MARTIN F. · 2002 to 2016
$16.5M
Racial and Cardiovascular Risk Factor Anomalies in CKDR01DK096920 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI KALANTAR-ZADEH, KAMYAR, KOVESDY, CSABA PAL · 2013 to 2015
$909k
HSRD VA SDR 02-237NCATS NIH HHS UL1 TR000124NIA NIH HHS P30 AG021684NIDDK NIH HHS R01 DK096920NIMHD NIH HHS P20 MD000182
6 · The paper itself

Abstract

backgroundIn the general population, compared wtih their White peers, African Americans suffer premature all-cause and cardiovascular (CV) deaths, attributed in part to reduced access to care and lower socioeconomic status. Prior reports indicated younger (aged 35 to 44 years) African Americans had a signficantly greater age-adjusted risk of death. Recent studies suggest that in a more egalitarian health care structure than typical United States (US) health care structures, African Americans may have similar or even better CV outcomes, but the impact of age is less well-known.

methodsWe examined age stratified all-cause mortality, and incident coronary heart disease (CHD) and ischemic stroke in 3,072,966 patients (547,441 African American and 2,525,525 White) with an estimated glomerular filtration rate (eGFR)>60 mL/min/1.73m(2) receiving care from the US Veterans Health Administration. Outcomes were examined in Cox models adjusted for demographics, comorbidities, kidney function, blood pressure, socioeconomics and indicators of the quality of health care delivery.

resultsAfrican Americans had an overall 30% lower all-cause mortality (P<.001) and 29% lower incidence of CHD (P<.001) and higher incidence of ischemic stroke (aHR, 95%CI: 1.16, 1.13-1.18, P<.001). The lower rates of mortality and CHD were strongest in younger African Americans and attenuated across patients aged ≥70 years. Stroke rates did not differ by race in persons aged <70 years.

conclusionsAmong patients with normal eGFR and receiving care in the Veterans Health Administration, younger African Americans had lower all-cause mortality and incidence of CHD and similar rates of stroke, independent of demographic, comorbidity and socioeconomic differences. The lower all-cause mortality persisted but attenuated with increasing age and the lower incidence of CHD ended at aged ≥80 years. The higher incidence of ischemic stroke in African Americans was driven by increasing risk in patients aged ≥70 years suggesting that the improved cardiovascular outcomes were most dramatic for younger African Americans.

Indexed as

Black or African AmericanVeteransAgedAged, 80 and overBlood PressureComorbidityCoronary DiseaseFemaleGlomerular Filtration RateHumansIncidenceMaleMiddle AgedProportional Hazards ModelsRacial GroupsStrokeAfrican AmericanAgeChronic Kidney DiseaseCoronary Heart DiseaseIncidenceMortalityRaceStroke

Identifiers

PMID27440969
PMCPMC4948796
OpenAlexW2506406159

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.