Evidence map›Paper›PMID 27440951›Full record

ArticleJournal of pharmacology & pharmacotherapeutics

Factors influencing adherence to anti-craving medications and drinking outcomes in patients with alcohol dependence: A hospital-based study.

K Lohit, Chanda Kulkarni, R B Galgali

Abstract read
In one paragraph

Article in Journal of pharmacology & pharmacotherapeutics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Alcohol use disorder research in India: An update.Indian journal of psychiatry · 2024
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

3 authors.

K LohitDepartment of Pharmacology, Sri Siddhartha Medical College, Tumakuru, Karnataka, India.
Chanda KulkarniDivision of Clinical Pharmacology, St. John's Medical College and Hospital, Bengaluru, Karnataka, India.
R B GalgaliDepartment of Psychiatry, St. John's Medical College and Hospital, Bengaluru, Karnataka, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine the factors influencing the pattern and extent of anti-craving medication adherence and drinking outcomes in alcohol-dependent patients. MATERIALS AND

methodsDemographic data from 102 inpatients were collected at discharge from hospital. The pattern of anti-craving medication, extent of adherence, and drinking outcome was collected at 1(st), 3(rd), 8(th), and 12(th) week follow-up. Patients' self-reported adherence, medication diary, and simplified medication adherence questionnaire were used and data were analyzed using SPSS.

resultsMajority (99%) were male patients with a mean age of 41.17 ± 9.86 years and 70% belonged to middle socioeconomic status. There was a decrease in the number of patients coming for follow-up over time from 99.01% to 77.45% on day 90. Acamprosate was used in 74% and naltrexone and disulfiram in 7% of patients each. A significant reduction in adherence to acamprosate and naltrexone (P < 0.001) was associated with simultaneous decrease in days to alcohol abstinence and increase in relapse rate compared to adherent group (P < 0.001). Main barriers to adherence included younger age (odds ratio = 1.05 95% [1.01-1.09]; P < 0.01), self-decision, emotional factors, and adverse effects.

conclusionsThe study demonstrated the need for safer therapeutic options along with suitable intervention at grass root level for sustenance of adherence to anti-craving medication among young adults to prevent relapse and achieve near-complete abstinence from alcohol dependence.

Indexed as

Acamprosateadherencealcohol dependenceanti-craving medicationsdrinking outcomes

Identifiers

PMID27440951
PMCPMC4936082

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.