Evidence map›Paper›PMID 27440911›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2017

Low Birth Weight and Risk of Later-Life Physical Disability in Women.

Cassandra N Spracklen, Kelli K Ryckman, Jennifer G Robinson, Marcia L Stefanick, Gloria E Sarto, Stephen D Anton, Robert B Wallace

Open access · bronzeAbstract read
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Preterm birth, birthweight, and subsequent risk for depression.Journal of developmental origins of health and disease · 2023
    Article
  5. Article
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Cassandra N SpracklenDepartment of Genetics, University of North Carolina-Chapel Hill.
Kelli K RyckmanDepartment of Epidemiology, University of Iowa College of Public Health, Iowa City.
Jennifer G RobinsonDepartment of Epidemiology, University of Iowa College of Public Health, Iowa City.
Marcia L StefanickDepartment of Medicine, Stanford University, California.
Gloria E SartoDepartment of Obstetrics and Gynecology, University of Wisconsin, Madison.
Stephen D AntonDepartment of Aging and Geriatric Medicine, University of Florida, Gainsville.
Robert B WallaceDepartment of Epidemiology, University of Iowa College of Public Health, Iowa City.
University of Iowa · USStanford University · USUniversity of North Carolina at Chapel Hill · USUniversity of Wisconsin–Madison · US

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Peihua Qiu · 2007 to 2026
$22.8M
XANTHINE OXIDASE PRODUCTS IN MODULATION OF ENDOTHELIAL DYSFUNCTIONM01RR000059 · NCRR · UNIVERSITY OF IOWA · PI MCLENNAN, GEOFFREY · 1985 to 2007
$22.3M
NCRR NIH HHS M01 RR000059NIA NIH HHS P30 AG028740
6 · The paper itself

Abstract

backgroundThere is strong evidence that low and high birth weight due to in-utero programming results in elevated risk for adult diseases, though less research has been performed examining the influence of birth weight and physical disability later in life.

methodsBaseline data from 76,055 postmenopausal women in the Women's Health Initiative, a large multi-ethnic cohort, were used to examine the association between self-reported birth weight category (<6 lbs, 6-7 lbs 15 oz, 8-9 lbs 15 oz, and ≥10 lbs) and the self-reported physical functioning score on the RAND 36-item Health Survey. Linear regression models were adjusted for age, education, race/ethnicity, body mass index, and a comorbidity score.

resultsUnadjusted models indicate that women born in the lowest and highest birth weight categories have significantly lower physical functioning scores as compared to women born in the normal weight category (β = -2.22, p < .0001 and β = -3.56, p < .0001, respectively). After adjustments, the relationship between the lowest birth weight category and physical functioning score remained significant (β = -1.52, p < .0001); however, the association with the highest birth weight category dissipated.

conclusionsPreconception and prenatal interventions aimed at reducing the incidence of low birth weight infants may subsequently reduce the burden of later-life physical disability.

Indexed as

AgedCross-Sectional StudiesDevelopmental DisabilitiesFemaleHumansInfant, Low Birth WeightMiddle AgedRetrospective StudiesRisk FactorsBirth weightDevelopmental Origins of Health and Disease hypothesisPhysical disabilityPhysical functioning

Identifiers

PMID27440911
PMCPMC6075587
OpenAlexW2499954678

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.