Evidence map›Paper›PMID 27440885›Full record

ArticleJournal of virology2016

Assessing Host-Virus Codivergence for Close Relatives of Merkel Cell Polyomavirus Infecting African Great Apes.

Nadège F Madinda, Bernhard Ehlers, Joel O Wertheim, Chantal Akoua-Koffi, Richard A Bergl, Christophe Boesch, Dieudonné Boji Mungu Akonkwa, Winnie Eckardt, Barbara Fruth, Thomas R Gillespie and 18 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 16 institutions in 12 countries.

Nadège F MadindaEpidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute, Berlin, Germany Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany Institut de Recherches en Ecologie Tropicale, Libreville, Gabon.
Bernhard EhlersFG12, Measles, Mumps, Rubella and Viruses Affecting Immunocompromised Patients, Robert Koch Institute, Berlin, Germany.
Joel O WertheimDepartment of Medicine, University of California, San Diego, California, USA.
Chantal Akoua-KoffiCentre de Recherche pour le Développement, Université Alassane Ouattara de Bouake, Bouake, Côte d'Ivoire.
Richard A BerglNorth Carolina Zoological Park, Asheboro, North Carolina, USA.
Christophe BoeschDepartment of Primatology, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
Dieudonné Boji Mungu AkonkwaInstitut Congolais pour la Conservation de la Nature, Kinshasa, Democratic Republic of Congo.
Winnie EckardtDiane Fossey Gorilla Fund International, Atlanta, Georgia, USA Department of Environmental Sciences and Program in Population Biology, Ecology and Evolution, Emory University, Druid Hills, Georgia, USA.
Barbara FruthDivision of Neurobiology, Ludwig Maximilians University, Munich, Germany Centre for Research and Conservation, Royal Zoological Society of Antwerp, Antwerp, Belgium.
Thomas R GillespieDepartment of Environmental Sciences and Program in Population Biology, Ecology and Evolution, Emory University, Druid Hills, Georgia, USA Department of Environmental Health, Rollins School of Public Health, Emory University, Druid Hills, Georgia, USA.
Maryke GrayInternational Gorilla Conservation Program, Kigali, Rwanda.
Gottfried HohmannDepartment of Primatology, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
Stomy KarhemereInstitut National de Recherche Biomédicale, Kinshasa, Democratic Republic of Congo.
Deo KujirakwinjaWildlife Conservation Society, Grauer's Gorilla Project, Kinshasa-Gombe, Democratic Republic of Congo.
Kevin LangergraberDepartment of Primatology, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany School of Human Evolution and Social Change, Arizona State University, Tempe, Arizona, USA.
Jean-Jacques MuyembeInstitut National de Recherche Biomédicale, Kinshasa, Democratic Republic of Congo.
Radar NishuliInstitut Congolais pour la Conservation de la Nature, Kinshasa, Democratic Republic of Congo.
Maude PaulyEpidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute, Berlin, Germany FG12, Measles, Mumps, Rubella and Viruses Affecting Immunocompromised Patients, Robert Koch Institute, Berlin, Germany.
Klara J PetrzelkovaInstitute of Vertebrate Biology, Academy of Sciences, Brno, Czech Republic Department of Pathology and Parasitology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic Biology Centre, Institute of Parasitology, Academy of Sciences of the Czech Republic, Ceske Budejovice, Czech Republic Liberec Zoo, Liberec, Czech Republic.
Martha M RobbinsDepartment of Primatology, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
Angelique ToddWorld Wildlife Foundation, Dzanga Sangha Protected Areas, Bangui, Central African Republic.
Grit SchubertEpidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute, Berlin, Germany.
Tara S StoinskiDiane Fossey Gorilla Fund International, Atlanta, Georgia, USA Department of Environmental Sciences and Program in Population Biology, Ecology and Evolution, Emory University, Druid Hills, Georgia, USA.
Roman M WittigDepartment of Primatology, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany Taï Chimpanzee Project, Centre Suisse de Recherches Scientifiques, Abidjan, Côte d'Ivoire.
Klaus ZuberbühlerInstitute of Biology, University of Neuchatel, Neuchatel, Switzerland Budongo Conservation Field Station, Masindi, Uganda School of Psychology, University of St. Andrews, St. Andrews, Scotland, United Kingdom.
Martine PeetersUnité Mixte Internationale 233, Institut de Recherche pour le Développement, INSERM U1175, and University of Montpellier, Montpellier, France Computational Biology Institute, Montpellier, France.
Fabian H LeendertzEpidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute, Berlin, Germany.
Sébastien Calvignac-SpencerEpidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute, Berlin, Germany calvignacs@rki.de.
Robert Koch Institute · DEMax Planck Institute for Evolutionary Anthropology · DEEmory University · USNational Institute of Biomedical Research · CDAfrican Wildlife Foundation · USArizona State University · USInstitut de Recherche pour le Développement · FRInternational Gorilla Conservation Programme · RWNorth Carolina Zoo Society · USRoyal Zoological Society of Antwerp · BEThe Dian Fossey Gorilla Fund International · USUniversité Alassane Ouattara · CIUniversity of California, San Diego · USUniversity of Neuchâtel · CHUniversity of Veterinary Sciences Brno · CZWildlife Conservation Society Congo · CG

Funding

Public Health Implications of HIV Transmission NetworksK01AI110181 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WERTHEIM, JOEL OKRENT · 2014 to 2018
$668k
NIAID NIH HHS K01 AI110181
6 · The paper itself

Abstract

unlabelledIt has long been hypothesized that polyomaviruses (PyV; family Polyomaviridae) codiverged with their animal hosts. In contrast, recent analyses suggested that codivergence may only marginally influence the evolution of PyV. We reassess this question by focusing on a single lineage of PyV infecting hominine hosts, the Merkel cell polyomavirus (MCPyV) lineage. By characterizing the genetic diversity of these viruses in seven African great ape taxa, we show that they exhibit very strong host specificity. Reconciliation analyses identify more codivergence than noncodivergence events. In addition, we find that a number of host and PyV divergence events are synchronous. Collectively, our results support codivergence as the dominant process at play during the evolution of the MCPyV lineage. More generally, our results add to the growing body of evidence suggesting an ancient and stable association of PyV and their animal hosts. IMPORTANCE: The processes involved in viral evolution and the interaction of viruses with their hosts are of great scientific interest and public health relevance. It has long been thought that the genetic diversity of double-stranded DNA viruses was generated over long periods of time, similar to typical host evolutionary timescales. This was also hypothesized for polyomaviruses (family Polyomaviridae), a group comprising several human pathogens, but this remains a point of controversy. Here, we investigate this question by focusing on a single lineage of polyomaviruses that infect both humans and their closest relatives, the African great apes. We show that these viruses exhibit considerable host specificity and that their evolution largely mirrors that of their hosts, suggesting that codivergence with their hosts played a major role in their diversification. Our results provide statistical evidence in favor of an association of polyomaviruses and their hosts over millions of years.

Indexed as

Evolution, MolecularGenetic VariationHost SpecificityAfricaAnimalsHominidaeMerkel cell polyomavirusPolyomavirus InfectionsTumor Virus Infections

Identifiers

PMID27440885
PMCPMC5021428
OpenAlexW2502785122

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.