ArticlePlant physiology2016
FUM2, a Cytosolic Fumarase, Is Essential for Acclimation to Low Temperature in Arabidopsis thaliana.
Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 56 citations in OpenAlex.
- Expression and Promoter Methylation of the Genes Encoding the Mitochondrial and Cytosolic Forms of Fumarase in Sunflower (Current issues in molecular biology · 2026Article
- Article
- Integrative Profiling of Phytohormones, Metabolomics, and Transcriptomics Reveals Key Regulators of Cold Tolerance in Cucumber Leaves.Food science & nutrition · 2025Article
- Systemic analysis of metabolome reconfiguration in Arabidopsis after abiotic stressors uncovers metabolites that modulate defense against pathogens.Plant communications · 2024Article
- Comparison of transcriptome and metabolome analysis revealed cold-resistant metabolic pathways in cucumber roots under low-temperature stress in root zone.Frontiers in plant science · 2024Article
- Metabolome plasticity in 241 Arabidopsis thaliana accessions reveals evolutionary cold adaptation processes.Plant physiology · 2023Article
- Photosynthetic acclimation to changing environments.Biochemical Society transactions · 2023Review
- Nucleotide Imbalance, Provoked by Downregulation of Aspartate Transcarbamoylase Impairs Cold Acclimation in Arabidopsis.Molecules (Basel, Switzerland) · 2023Article
- CAM photosynthesis: the acid test.The New phytologist · 2022Article
- The Interaction Between CitMYB52 and CitbHLH2 Negatively Regulates Citrate Accumulation by ActivatingFrontiers in plant science · 2022Article
- Emerging Role of TCA Cycle-Related Enzymes in Human Diseases.International journal of molecular sciences · 2021Review
- mRNA surveillance complex PELOTA-HBS1 regulates phosphoinositide-dependent protein kinase1 and plant growth.Plant physiology · 2021Article
- Central Metabolism in Mammals and Plants as a Hub for Controlling Cell Fate.Antioxidants & redox signaling · 2021Review
- Investigation of the effects of P1 on HC-pro-mediated gene silencing suppression through genetics and omics approaches.Botanical studies · 2020Article
- Translational Components Contribute to Acclimation Responses to High Light, Heat, and Cold in Arabidopsis.iScience · 2020Article
- From empirical to theoretical models of light response curves - linking photosynthetic and metabolic acclimation.Photosynthesis research · 2020Article
- Consequences of Oxidative Stress on Plant Glycolytic and Respiratory Metabolism.Frontiers in plant science · 2019Review
- Flux sampling is a powerful tool to study metabolism under changing environmental conditions.NPJ systems biology and applications · 2019Article
- The Role of Abscisic Acid Signaling in Maintaining the Metabolic Balance Required for Arabidopsis Growth under Nonstress Conditions.The Plant cell · 2019Article
- Citrus CitNAC62 cooperates with CitWRKY1 to participate in citric acid degradation via up-regulation of CitAco3.Journal of experimental botany · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
Abstract
Although cold acclimation is a key process in plants from temperate climates, the mechanisms sensing low temperature remain obscure. Here, we show that the accumulation of the organic acid fumaric acid, mediated by the cytosolic fumarase FUM2, is essential for cold acclimation of metabolism in the cold-tolerant model species Arabidopsis (Arabidopsis thaliana). A nontargeted metabolomic approach, using gas chromatography-mass spectrometry, identifies fumarate as a key component of the cold response in this species. Plants of T-DNA insertion mutants, lacking FUM2, show marked differences in their response to cold, with contrasting responses both in terms of metabolite concentrations and gene expression. The fum2 plants accumulated higher concentrations of phosphorylated sugar intermediates and of starch and malate. Transcripts for proteins involved in photosynthesis were markedly down-regulated in fum2.2 but not in wild-type Columbia-0. Plants of fum2 show a complete loss of the ability to acclimate photosynthesis to low temperature. We conclude that fumarate accumulation plays an essential role in low temperature sensing in Arabidopsis, either indirectly modulating metabolic or redox signals or possibly being itself directly involved in cold sensing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.