ArticleAngewandte Chemie (International ed. in English)2016
An Epigenetics-Inspired DNA-Based Data Storage System.
Article in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- ZAT-DNA enables DNA data storage with molecular-layer non-replicability.Nature communications · 2026Article
- Towards next-generation DNA encryption via an expanded genetic system.National science review · 2025Article
- Recent progress in DNA data storage based on high-throughput DNA synthesis.Biomedical engineering letters · 2024Review
- CRISPR-powered quantitative keyword search engine in DNA data storage.Nature communications · 2024Article
- DNA Data Storage.Biotech (Basel (Switzerland)) · 2023Review
- Review
- In vivo processing of digital information molecularly with targeted specificity and robust reliability.Science advances · 2022Article
- TET-Like Oxidation in 5-Methylcytosine and Derivatives: A Computational and Experimental Study.Chembiochem : a European journal of chemical biology · 2021Article
- Advancing DNA Steganography with Incorporation of Randomness.Chembiochem : a European journal of chemical biology · 2020Article
- Photo-editable macromolecular information.Nature communications · 2019Article
- Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation.Nature chemistry · 2017Review
- Mass spectrometry sequencing of long digital polymers facilitated by programmed inter-byte fragmentation.Nature communications · 2017Article
- An Epigenetics-Inspired DNA-Based Data Storage System.Angewandte Chemie (International ed. in English) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Biopolymers are an attractive alternative to store and circulate information. DNA, for example, combines remarkable longevity with high data storage densities and has been demonstrated as a means for preserving digital information. Inspired by the dynamic, biological regulation of (epi)genetic information, we herein present how binary data can undergo controlled changes when encoded in synthetic DNA strands. By exploiting differential kinetics of hydrolytic deamination reactions of cytosine and its naturally occurring derivatives, we demonstrate how multiple layers of information can be stored in a single DNA template. Moreover, we show that controlled redox reactions allow for interconversion of these DNA-encoded layers of information. Overall, such interlacing of multiple messages on synthetic DNA libraries showcases the potential of chemical reactions to manipulate digital information on (bio)polymers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.