Evidence map›Paper›PMID 27440628›Full record

ArticleBritish journal of anaesthesia2016

Preoperative heart rate and myocardial injury after non-cardiac surgery: results of a predefined secondary analysis of the VISION study.

T E F Abbott, G L Ackland, R A Archbold, A Wragg, E Kam, T Ahmad, A W Khan, E Niebrzegowska, R N Rodseth, P J Devereaux and 1 more

Registry-linked trialOpen access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of anaesthesia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00512109 (Vascular Events In Noncardiac Surgery Patients Cohort Evaluation), which is not on this map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00512109 completednot on this map

Vascular Events In Noncardiac Surgery Patients Cohort Evaluation (VISION) Study

TypeobservationalSponsorMcMaster UniversityRan2007 to 2014Enrolled40,060ConditionsVascular Death, Myocardial Infarction, Cardiac Arrest, Stroke
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.

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  5. Myocardial injury in oncology patients undergoing noncardiac surgery for MRONJ: risk factors and nutritional associations.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

T E F AbbottWilliam Harvey Research Institute, Queen Mary University of London, London, UK.
G L AcklandWilliam Harvey Research Institute, Queen Mary University of London, London, UK.
R A ArchboldBarts Health NHS Trust, London, UK.
A WraggBarts Health NHS Trust, London, UK.
E KamWilliam Harvey Research Institute, Queen Mary University of London, London, UK.
T AhmadWilliam Harvey Research Institute, Queen Mary University of London, London, UK.
A W KhanShaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan.
E NiebrzegowskaBarts Health NHS Trust, London, UK.
R N RodsethNelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
P J DevereauxPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
R M PearseWilliam Harvey Research Institute, Queen Mary University of London, London, UK r.pearse@qmul.ac.uk.
Barts Health NHS Trust · GBQueen Mary University of London · GBWilliam Harvey Research Institute · GBPopulation Health Research Institute · CAShaukat Khanum Memorial Cancer Hospital and Research Center · PKUniversity of KwaZulu-Natal · ZA

Funding

Department of Health RP_2014-04-022Medical Research Council MR/M017974/1
6 · The paper itself

Abstract

backgroundIncreased baseline heart rate is associated with cardiovascular risk and all-cause mortality in the general population. We hypothesized that elevated preoperative heart rate increases the risk of myocardial injury after non-cardiac surgery (MINS).

methodsWe performed a secondary analysis of a prospective international cohort study of patients aged ≥45 yr undergoing non-cardiac surgery. Preoperative heart rate was defined as the last measurement before induction of anaesthesia. The sample was divided into deciles by heart rate. Multivariable logistic regression models were used to determine relationships between preoperative heart rate and MINS (determined by serum troponin concentration), myocardial infarction (MI), and death within 30 days of surgery. Separate models were used to test the relationship between these outcomes and predefined binary heart rate thresholds.

resultsPatients with missing outcomes or heart rate data were excluded from respective analyses. Of 15 087 patients, 1197 (7.9%) sustained MINS, 454 of 16 007 patients (2.8%) sustained MI, and 315 of 16 037 patients (2.0%) died. The highest heart rate decile (>96 beats min(-1)) was independently associated with MINS {odds ratio (OR) 1.48 [1.23-1.77]; P<0.01}, MI (OR 1.71 [1.34-2.18]; P<0.01), and mortality (OR 3.16 [2.45-4.07]; P<0.01). The lowest decile (<60 beats min(-1)) was independently associated with reduced mortality (OR 0.50 [0.29-0.88]; P=0.02), but not MINS or MI. The predefined binary thresholds were also associated with MINS, but more weakly than the highest heart rate decile.

conclusionsPreoperative heart rate >96 beats min(-1) is associated with MINS, MI, and mortality after non-cardiac surgery. This association persists after accounting for potential confounding factors. CLINICAL

trial registrationNCT00512109.

Indexed as

Preoperative CareSurgical Procedures, OperativeAgedCohort StudiesFemaleHeart RateHumansMaleMiddle AgedMyocardial IschemiaPostoperative ComplicationsProspective StudiesRisk AssessmentRisk Factorsheart rateobservational studysurgery

Identifiers

PMID27440628
PMCPMC4954612
OpenAlexW2497990902

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.