ArticleScientific reports2016
Identification of a diazinon-metabolizing glutathione S-transferase in the silkworm, Bombyx mori.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 55 citations in OpenAlex.
- RNAi-based functional analysis of a theta-class glutathione S-transferase implicated in deltamethrin detoxification inFrontiers in physiology · 2025Article
- Antioxidative and Antiglycative Stress Activities of Selenoglutathione Diselenide.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Article
- Transcriptomics and Proteomics ofAnimals : an open access journal from MDPI · 2023Article
- Antennal transcriptomic analysis of carboxylesterases and glutathione S-transferases associated with odorant degradation in the tea gray geometrid,Frontiers in physiology · 2023Article
- A chromosome-level genome assembly of the pollinating fig wasp Valisia javana.DNA research : an international journal for rapid publication of reports on genes and genomes · 2022Article
- Analysis of glutathione-S-transferases from larvae ofFrontiers in physiology · 2022Article
- Gut transcriptome of two bark beetle species stimulated with the same kairomones reveals molecular differences in detoxification pathways.Computational and structural biotechnology journal · 2022Article
- Structural and Functional Characterization of One Unclassified Glutathione S-Transferase in Xenobiotic Adaptation ofInternational journal of molecular sciences · 2021Article
- Article
- Environmental Occurrence, Toxicity Concerns, and Degradation of Diazinon Using a Microbial System.Frontiers in microbiology · 2021Review
- Investigation of the active site of an unclassified glutathione transferase inJournal of pesticide science · 2020Article
- Functional Analysis of an Epsilon-Class Glutathione S-Transferase From Nilaparvata lugens (Hemiptera: Delphacidae).Journal of insect science (Online) · 2019Article
- Molecular Biomarkers in Drug-Induced Liver Injury: Challenges and Future Perspectives.Frontiers in pharmacology · 2019Review
- Characterisation of a diazinon-metabolising glutathione S-transferase in the silkworm Bombyx mori by X-ray crystallography and genome editing analysis.Scientific reports · 2018Article
- Multiple Glutathione S-Transferase Genes in Heortia vitessoides (Lepidoptera: Crambidae): Identification and Expression Patterns.Journal of insect science (Online) · 2018Article
- Glutathione-S-Transferases in the Olfactory Organ of the Noctuid MothFrontiers in physiology · 2018Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The glutathione S-transferase superfamily play key roles in the metabolism of numerous xenobiotics. We report herein the identification and characterization of a novel glutathione S-transferase in the silkworm, Bombyx mori. The enzyme (bmGSTu2) conjugates glutathione to 1-chloro-2,4-dinitrobenzene, as well as metabolizing diazinon, one of the organophosphate insecticides. Quantitative reverse transcription-polymerase chain reaction analysis of transcripts demonstrated that bmGSTu2 expression was induced 1.7-fold in a resistant strain of B. mori. Mutagenesis of putative amino acid residues in the glutathione-binding site revealed that Ile54, Glu66, Ser67, and Asn68 are crucial for enzymatic function. These results provide insights into the catalysis of glutathione conjugation in silkworm by bmGSTu2 and into the detoxification of organophosphate insecticides.
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