ArticleJournal of neurophysiology2016
Vestibular nucleus neurons respond to hindlimb movement in the conscious cat.
Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Combined Effects of Vestibular Dysfunction and Mild Cognitive Impairment on Reactive Stepping Responses in Older Adults.Medicine and science in sports and exercise · 2026Article
- Habituation of vestibular-evoked balance responses after repeated exposure to a postural threat.The Journal of physiology · 2025Article
- Convergence of vestibular and proprioceptive signals in the cerebellar nodulus/uvula enhances the encoding of self-motion in primates.Current biology : CB · 2025Article
- Tau P301S Transgenic Mice Develop Gait and Eye Movement Impairments That Mimic Progressive Supranuclear Palsy.bioRxiv : the preprint server for biology · 2024Article
- Histaminergic System and Vestibular Function in Normal and Pathological Conditions.Current neuropharmacology · 2024Review
- Perinatal development of central vestibular neurons in mice.Frontiers in neuroscience · 2022Article
- Control of Mammalian Locomotion by Somatosensory Feedback.Comprehensive Physiology · 2021Article
- Integration of vestibular and hindlimb inputs by vestibular nucleus neurons: multisensory influences on postural control.Journal of neurophysiology · 2021Article
- Responses of neurons in the rostral ventrolateral medulla of conscious cats to anticipated and passive movements.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Responses of Neurons in the Medullary Lateral Tegmental Field and Nucleus Tractus Solitarius to Vestibular Stimuli in Conscious Felines.Frontiers in neurology · 2020Article
- Quantitative Evaluation of a New Posturo-Locomotor Phenotype in a Rodent Model of Acute Unilateral Vestibulopathy.Frontiers in neurology · 2020Article
- Hypergravity-induced plastic alteration of the vestibulo-sympathetic reflex involves decrease in responsiveness of CAMK2-expressing neurons in the vestibular nuclear complex.The journal of physiological sciences : JPS · 2019Article
- Predictive Sensing: The Role of Motor Signals in Sensory Processing.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Review
- Vestibular processing during natural self-motion: implications for perception and action.Nature reviews. Neuroscience · 2019Review
- Neurons in the pontomedullary reticular formation receive converging inputs from the hindlimb and labyrinth.Experimental brain research · 2017Article
- Descending Influences on Vestibulospinal and Vestibulosympathetic Reflexes.Frontiers in neurology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The limbs constitute the sole interface with the ground during most waking activities in mammalian species; it is therefore expected that somatosensory inputs from the limbs provide important information to the central nervous system for balance control. In the decerebrate cat model, the activity of a subset of neurons in the vestibular nuclei (VN) has been previously shown to be modulated by hindlimb movement. However, decerebration can profoundly alter the effects of sensory inputs on the activity of brain stem neurons, resulting in epiphenomenal responses. Thus, before this study, it was unclear whether and how somatosensory inputs from the limb affected the activity of VN neurons in conscious animals. We recorded brain stem neuronal activity in the conscious cat and characterized the responses of VN neurons to flexion and extension hindlimb movements and to whole body vertical tilts (vestibular stimulation). Among 96 VN neurons whose activity was modulated by vestibular stimulation, the firing rate of 65 neurons (67.7%) was also affected by passive hindlimb movement. VN neurons in conscious cats most commonly encoded hindlimb movement irrespective of the direction of movement (n = 33, 50.8%), in that they responded to all flexion and extension movements of the limb. Other VN neurons overtly encoded information about the direction of hindlimb movement (n = 27, 41.5%), and the remainder had more complex responses. These data confirm that hindlimb somatosensory and vestibular inputs converge onto VN neurons of the conscious cat, suggesting that VN neurons integrate somatosensory inputs from the limbs in computations that affect motor outflow to maintain balance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.