Evidence map›Paper›PMID 27440241›Full record

ArticleJournal of neurophysiology2016

Developmental regulation of inhibitory synaptic currents in the dorsal motor nucleus of the vagus in the rat.

Caitlin A McMenamin, Laura Anselmi, R Alberto Travagli, Kirsteen N Browning

Open access · greenAbstract read
In one paragraph

Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. GABAJournal of neurophysiology · 2019
    Article
  5. Extensive Inhibitory Gating of Viscerosensory Signals by a Sparse Network of Somatostatin Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
  6. Perinatal high-fat diet alters development of GABAAmerican journal of physiology. Gastrointestinal and liver physiology · 2019
    Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Caitlin A McMenaminDepartment of Neural and Behavioral Sciences, Penn State College of Medicine, Hershey, Pennsylvania.ORCID 0000-0002-7988-8406
Laura AnselmiDepartment of Neural and Behavioral Sciences, Penn State College of Medicine, Hershey, Pennsylvania.
R Alberto TravagliDepartment of Neural and Behavioral Sciences, Penn State College of Medicine, Hershey, Pennsylvania.
Kirsteen N BrowningDepartment of Neural and Behavioral Sciences, Penn State College of Medicine, Hershey, Pennsylvania knb13@psu.edu.ORCID 0000-0002-5062-3703
Penn State Milton S. Hershey Medical Center · US

Funding

Vagal Dysregulation in Neonatal Gastrointestinal PathologyR01DK099350 · NIDDK · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KOPENHAVER DOHENY, KIM, TRAVAGLI, RENATO ALBERTO · 2014 to 2017
$2.2M
NIDDK NIH HHS R01 DK099350
6 · The paper itself

Abstract

Prior immunohistochemical studies have demonstrated that at early postnatal time points, central vagal neurons receive both glycinergic and GABAergic inhibitory inputs. Functional studies have demonstrated, however, that adult vagal efferent motoneurons receive only inhibitory GABAergic synaptic inputs, suggesting loss of glycinergic inhibitory neurotransmission during postnatal development. The purpose of the present study was to test the hypothesis that the loss of glycinergic inhibitory synapses occurs in the immediate postnatal period. Whole cell patch-clamp recordings were made from dorsal motor nucleus of the vagus (DMV) neurons from postnatal days 1-30, and the effects of the GABA

Indexed as

AnimalsAnimals, NewbornBicucullineGABA-A Receptor AntagonistsGlycine AgentsImmunohistochemistryInhibitory Postsynaptic PotentialsMedulla OblongataMiniature Postsynaptic PotentialsNeuronsPatch-Clamp TechniquesRats, Sprague-DawleyReceptors, GABA-AReceptors, GlycineStrychnineTissue Culture TechniquesBicucullineGABA-A Receptor AntagonistsGlycine AgentsReceptors, GABA-AReceptors, GlycineStrychninebrain stemdevelopmentglycinevagusγ-aminobutyric acid

Identifiers

PMID27440241
PMCPMC5144697
OpenAlexW2499048621

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.