ArticleJournal of clinical hypertension (Greenwich, Conn.)2017
Prevalence of Homocysteine-Related Hypertension in Patients With Chronic Kidney Disease.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Pooled it
- Evidence on the causal link between homocysteine and hypertension from a meta-analysis of 40 173 individuals implementing Mendelian randomization.Journal of clinical hypertension (Greenwich, Conn.) · 2019Pooled it
- The relationship between homocysteine levels and blood pressure variability with early renal injury marker NGAL in patients with H-type hypertension.BMC cardiovascular disorders · 2025Article
- A retrospective cohort study of H-type hypertension and its influence on the prognostic effect in patients with non-dialysis CKD.Frontiers in nutrition · 2025Article
- Design, Synthesis, and Study of a NovelACS omega · 2022Article
- Resveratrol: A new approach to ameliorate hyperhomocysteinaemia-induced renal dysfunction.Experimental and therapeutic medicine · 2022Article
- Impact of H-Type Hypertension on Intraplaque Neovascularization Assessed by Contrast-Enhanced Ultrasound.Journal of atherosclerosis and thrombosis · 2022Article
- Co-existing Hypertension and Hyperhomocysteinemia Increases the Risk of Carotid Vulnerable Plaque and Subsequent Vascular Event: An MR Vessel Wall Imaging Study.Frontiers in cardiovascular medicine · 2022Article
- The association between retinal vessel abnormalities and H-type hypertension.BMC neurology · 2021Article
- Homocysteine level is positively and independently associated with serum creatinine and urea nitrogen levels in old male patients with hypertension.Scientific reports · 2020Article
- Observational
- A risk scoring system for the decreased glomerular filtration rate in Chinese general population.Journal of clinical laboratory analysis · 2020Article
- Comparison of serum Lp-PLA2 levels in ischemic stroke patients with H-type hypertension or non-H-type hypertension.Journal of clinical laboratory analysis · 2020Article
- Prevalence and Associated Risk Factors of Chronic Kidney Disease in an Elderly Population from Eastern China.International journal of environmental research and public health · 2019Article
- Relation of four nontraditional lipid profiles to diabetes in rural Chinese H-type hypertension population.Lipids in health and disease · 2017Article
- Homocysteine and hydrogen sulfide in epigenetic, metabolic and microbiota related renovascular hypertension.Pharmacological research · 2016Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with both hypertension and hyperhomocysteinemia, termed H-type hypertension, have a high risk for cardiocerebrovascular diseases. However, little is known about the prevalence of H-type hypertension or its role in target organ damage in patients with chronic kidney disease (CKD). The authors recruited 1042 patients with CKD who were admitted to their hospital division. Multiple linear regression analyses were used to evaluate the association between H-type hypertension and renal/cardiovascular parameters. A total of 460 (44.14%) CKD patients had H-type hypertension. Multivariate logistic regression analysis showed that H-type hypertension is associated with serum albumin, uric acid, estimated glomerular filtration rate (eGFR), and 24-hour systolic blood pressure. Patients with H-type hypertension had the worst renal function and left ventricular hypertrophy among all patients, while the levels of carotid intima-media thickness (cIMT) in patients with H-type hypertension were only slightly higher than in patients with normotension and normohomocysteinemia (P<.05). H-type hypertension was associated with eGFR, left ventricular mass index, and cIMT according to multiple linear regression analyses. The prevalence of H-type hypertension was high and H-type hypertension was associated with target organ damage in patients with CKD.
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