ArticleScientific reports2016
Targeting of the circadian clock via CK1δ/ε to improve glucose homeostasis in obesity.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 39 citations in OpenAlex.
- Circadian clock and its potential as a therapy for ischemic heart disease.Cell communication and signaling : CCS · 2026Review
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- Expression of CSNK1D in lung adenocarcinoma and its prognostic value after surgery.Discover oncology · 2026Article
- Gut microbiome-produced bile acid metabolite lengthens the circadian period in host intestinal cells.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Guideline-informed care for osteoarthritis: Support needs of community pharmacists and healthcare professionals in Nigeria, West-Africa.Osteoarthritis and cartilage open · 2025Article
- Unsaturated fat alters clock phosphorylation to align rhythms to the season in mice.Science (New York, N.Y.) · 2025Article
- Inhibition of Casein Kinase 1International journal of molecular sciences · 2025Article
- The metabolic significance of peripheral tissue clocks.Communications biology · 2025Review
- Article
- Fibroblast-like synoviocytes orchestrate daily rhythmic inflammation in arthritis.Open biology · 2024Article
- Structural Investigations on 2-Amidobenzimidazole Derivatives as New Inhibitors of Protein Kinase CK1 Delta.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Time-restricted feeding restores metabolic flexibility in adult mice with excess adiposity.Frontiers in nutrition · 2024Article
- Effect of circadian clock disruption on type 2 diabetes.Frontiers in physiology · 2024Review
- Article
- PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic Rhythms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Article
- Circadian clock function does not require the histone methyltransferase MLL3.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Chronic inflammatory arthritis drives systemic changes in circadian energy metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- CK2 and protein kinases of the CK1 superfamily as targets for neurodegenerative disorders.Frontiers in molecular biosciences · 2022Review
- Casein Kinase 1 and Human Disease: Insights From the Circadian Phosphoswitch.Frontiers in molecular biosciences · 2022Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Growing evidence indicates that disruption of our internal timing system contributes to the incidence and severity of metabolic diseases, including obesity and type 2 diabetes. This is perhaps not surprising since components of the circadian clockwork are tightly coupled to metabolic processes across the body. In the current study, we assessed the impact of obesity on the circadian system in mice at a behavioural and molecular level, and determined whether pharmacological targeting of casein kinase 1δ and ε (CK1δ/ε), key regulators of the circadian clock, can confer metabolic benefit. We demonstrate that although behavioural rhythmicity was maintained in diet-induced obesity (DIO), gene expression profiling revealed tissue-specific alteration to the phase and amplitude of the molecular clockwork. Clock function was most significantly attenuated in visceral white adipose tissue (WAT) of DIO mice, and was coincident with elevated tissue inflammation, and dysregulation of clock-coupled metabolic regulators PPARα/γ. Further, we show that daily administration of a CK1δ/ε inhibitor (PF-5006739) improved glucose tolerance in both DIO and genetic (ob/ob) models of obesity. These data further implicate circadian clock disruption in obesity and associated metabolic disturbance, and suggest that targeting of the clock represents a therapeutic avenue for the treatment of metabolic disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.