ArticleJournal of human genetics2016
Genetic-risk assessment of GWAS-derived susceptibility loci for type 2 diabetes in a 10 year follow-up of a population-based cohort study.
Article in Journal of human genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- ECG features improve multimodal deep learning prediction of incident T2DM in a Middle Eastern cohort.Scientific reports · 2025Article
- Identification of Novel Genetic Variants and Food Intake Factors Associated with Type 2 Diabetes in South Korean Adults, Using an Illness-Death Model.International journal of molecular sciences · 2025Article
- Genome-wide identification and functional validation of the WW domain containing oxidoreductase gene associated with sleep duration.Scientific reports · 2025Article
- A perspective on genetic and polygenic risk scores-advances and limitations and overview of associated tools.Briefings in bioinformatics · 2024Review
- The clinical relevance of a polygenic risk score for type 2 diabetes mellitus in the Korean population.Scientific reports · 2024Article
- Interactions of genetic variations in FAS, GJB2 and PTPRN2 are associated with noise-induced hearing loss: a case-control study in China.BMC medical genomics · 2024Article
- Genetics of diabetes.World journal of diabetes · 2023Review
- Relationship between glucose homeostasis and obesity in early life-a study of Italian children and adolescents.Human molecular genetics · 2022Article
- Knowledge discovery in genetics of diabetes in Iran, a roadmap for future researches.Journal of diabetes and metabolic disorders · 2021Review
- Integrative genomics approach identifies conserved transcriptomic networks in Alzheimer's disease.Human molecular genetics · 2020Article
- Screening of noise-induced hearing loss (NIHL)-associated SNPs and the assessment of its genetic susceptibility.Environmental health : a global access science source · 2019Article
- Genetic variants associated with patent ductus arteriosus in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Genetic risk score of common genetic variants for impaired fasting glucose and newly diagnosed type 2 diabetes influences oxidative stress.Scientific reports · 2018Article
- Prospective association of a genetic risk score with major adverse cardiovascular events in patients with coronary artery disease.Medicine · 2017Article
- Genetic risk scores in the prediction of plasma glucose, impaired insulin secretion, insulin resistance and incident type 2 diabetes in the METSIM study.Diabetologia · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
To date, genome-wide meta-analyses have identified genetic susceptibility to type 2 diabetes mellitus (T2D) predominantly in populations of European ancestry. However, comprehensive genetic-risk assessment based on previous GWAS loci has not been fully tested in non-European populations. To evaluate whether a genetic-risk score (GRS) could improve T2D-risk prediction in the Korean population, a GRS (GRS-55) was constructed by summing 55 risk alleles based on the 1000 Genomes imputation in the Korean Association Resource study (T2D cases=1042 and controls=2943 at baseline). We also constructed another GRS (GRS-19) based on nominal significance and consistent direction of effect. In mean difference tests, the mean value of the GRS-19 was significantly higher in T2D cases than in controls at baseline examination. In a model adjusted for area, age, sex and body mass index, weighted GRS-19 was found to be associated with enhanced effect sizes of T2D risk under consistent C-statistics. In addition, we confirmed cumulative risk effects on incidence rates of T2D, fasting plasma glucose and glycated hemoglobin (HbA1c) levels in a longitudinal 10 year of follow-up study. These findings highlight that a genotype score comprised of 19 common variants contributed to T2D-risk prediction in the Korean population. Further multi-locus epistatic interactions may provide the possibility to improve risk prediction in C-statistics for discrimination or reclassification.
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