Evidence map›Paper›PMID 27439604›Full record

ArticleBMB reports2016

Cordycepin inhibits chondrocyte hypertrophy of mesenchymal stem cells through PI3K/Bapx1 and Notch signaling pathway.

Zhen Cao, Ce Dou, Jianmei Li, Xiangyu Tang, Junyu Xiang, Chunrong Zhao, Lingyu Zhu, Yun Bai, Qiang Xiang, Shiwu Dong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMB reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Zhen CaoDepartment of Anatomy, Third Military Medical University and National & Regional United Engineering Laboratory of Tissue Engineering, Department of Biomedical Materials Science, School of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China.
Ce DouNational & Regional United Engineering Laboratory of Tissue Engineering, Department of Biomedical Materials Science, School of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China.
Jianmei LiNational & Regional United Engineering Laboratory of Tissue Engineering, Department of Biomedical Materials Science, School of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China.
Xiangyu TangNational & Regional United Engineering Laboratory of Tissue Engineering, Department of Biomedical Materials Science, School of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China.
Junyu XiangNational & Regional United Engineering Laboratory of Tissue Engineering, Department of Biomedical Materials Science, School of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China.
Chunrong ZhaoNational & Regional United Engineering Laboratory of Tissue Engineering, Department of Biomedical Materials Science, School of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China.
Lingyu ZhuNational & Regional United Engineering Laboratory of Tissue Engineering, Department of Biomedical Materials Science, School of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China.
Yun BaiNational & Regional United Engineering Laboratory of Tissue Engineering, Department of Biomedical Materials Science, School of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China.
Qiang XiangDepartment of Emergency, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Shiwu DongNational & Regional United Engineering Laboratory of Tissue Engineering, Department of Biomedical Materials Science, School of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China.
Army Medical University · CNSouthwest Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) are widely used in cartilage tissue engineering to repair articular cartilage defects. However, hypertrophy of chondrocytes derived from MSCs might hinder the stabilization of hyaline cartilage. Thus, it is very important to find a suitable way to maintain the chondrogenic phenotype of chondrocytes. It has been reported that cordycepin has anti-inflammatory and anti-tumor functions. However, the role of cordycepin in chondrocyte hypertrophy remains unclear. Therefore, the objective of this study was to determine the effect of cordycepin on chondrogenesis and chondrocyte hypertrophy in MSCs and ATDC5 cells. Cordycepin upregulated chondrogenic markers including Sox9 and collagen type II while down-regulated hypertrophic markers including Runx2 and collagen type X. Further exploration showed that cordycepin promoted chondrogenesis through inhibiting Nrf2 while activating BMP signaling. Besides, cordycepin suppressed chondrocyte hypertrophy through PI3K/Bapx1 pathway and Notch signaling. Our results indicated cordycepin had the potential to maintain chondrocyte phenotype and reconstruct engineered cartilage. [BMB Reports 2016; 49(10): 548-553].

Indexed as

Antineoplastic AgentsCell DifferentiationCells, CulturedChondrocytesChondrogenesisCollagen Type IICollagen Type XCore Binding Factor Alpha 1 SubunitDeoxyadenosinesDown-RegulationHomeodomain ProteinsHumansMesenchymal Stem CellsNF-E2-Related Factor 2Phosphatidylinositol 3-KinasesReal-Time Polymerase Chain ReactionAntineoplastic AgentsCollagen Type IICollagen Type XcordycepinCore Binding Factor Alpha 1 SubunitDeoxyadenosinesHomeodomain ProteinsNFE2L2 protein, humanNF-E2-Related Factor 2NKX3-2 protein, humanPhosphatidylinositol 3-KinasesReceptors, NotchSOX9 protein, humanSOX9 Transcription FactorTranscription Factors

Identifiers

PMID27439604
PMCPMC5227296
OpenAlexW2496490719

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.