ArticleVeterinary research2016
Distinct immune responses of juvenile and adult oysters (Crassostrea gigas) to viral and bacterial infections.
Article in Veterinary research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 59 citations in OpenAlex.
- A Comparison of Juvenile and Adult Sunflower Sea Star Transcriptomic Responses to Challenge With Sea Star Wasting Disease Tissue Homogenates.Ecology and evolution · 2026Article
- Multiple evolutionary routes to immune diversification across animals.International immunology · 2026Review
- Temporal and spatial co-occurrence of pacific oyster mortality and increased planktoniciScience · 2025Article
- Semi-purified Antimicrobial Proteins from Oyster Hemolymph Inhibit Pneumococcal Infection.Marine biotechnology (New York, N.Y.) · 2024Article
- Temperature and microbe mediated impacts of the San Diego Bay ostreid herpesvirus (OsHV-1) microvariant on juvenile Pacific oysters.Sustainable microbiology · 2024Article
- The Evolution of the Age of Onset of Resistance to Infectious Disease.Bulletin of mathematical biology · 2023Article
- The evolution of age-specific resistance to infectious disease.Proceedings. Biological sciences · 2023Article
- In search of the Aplysia immunome: an in silico study.BMC genomics · 2022Article
- A Deterministic Model for Understanding Nonlinear Viral Dynamics in Oysters.Applied and environmental microbiology · 2022Article
- The expanded inhibitor of apoptosis gene family in oysters possesses novel domain architectures and may play diverse roles in apoptosis following immune challenge.BMC genomics · 2022Article
- The Role of Anti-Viral Effector Molecules in Mollusc Hemolymph.Biomolecules · 2022Review
- Article
- Immune Control of Herpesvirus Infection in Molluscs.Pathogens (Basel, Switzerland) · 2020Review
- Article
- Article
- Simulated Marine Heat Wave Alters Abundance and Structure of Vibrio Populations Associated with the Pacific Oyster Resulting in a Mass Mortality Event.Microbial ecology · 2019Article
- Molecular and cellular characterization of apoptosis in flat oyster a key mechanisms at the heart of host-parasite interactions.Scientific reports · 2018Article
- Review
- Long-lasting antiviral innate immune priming in the Lophotrochozoan Pacific oyster, Crassostrea gigas.Scientific reports · 2017Article
- New Insights into Pathogenic Vibrios Affecting Bivalves in Hatcheries: Present and Future Prospects.Frontiers in microbiology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since 2008, massive mortality events of Pacific oysters (Crassostrea gigas) have been reported worldwide and these disease events are often associated with Ostreid herpesvirus type 1 (OsHV-1). Epidemiological field studies have also reported oyster age and other pathogens of the Vibrio genus are contributing factors to this syndrome. We undertook a controlled laboratory experiment to simultaneously investigate survival and immunological response of juvenile and adult C. gigas at different time-points post-infection with OsHV-1, Vibrio tasmaniensis LGP32 and V. aestuarianus. Our data corroborates epidemiological studies that juveniles are more susceptible to OsHV-1, whereas adults are more susceptible to Vibrio. We measured the expression of 102 immune-genes by high-throughput RT-qPCR, which revealed oysters have different transcriptional responses to OsHV-1 and Vibrio. The transcriptional response in the early stages of OsHV-1 infection involved genes related to apoptosis and the interferon-pathway. Transcriptional response to Vibrio infection involved antimicrobial peptides, heat shock proteins and galectins. Interestingly, oysters in the later stages of OsHV-1 infection had a transcriptional response that resembled an antibacterial response, which is suggestive of the oyster's microbiome causing secondary infections (dysbiosis-driven pathology). This study provides molecular evidence that oysters can mount distinct immune response to viral and bacterial pathogens and these responses differ depending on the age of the host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.