Evidence map›Paper›PMID 27439448›Full record

ArticleEuropean journal of clinical pharmacology2016

The P450 oxidoreductase (POR) rs2868177 and cytochrome P450 (CYP) 2B6*6 polymorphisms contribute to the interindividual variability in human CYP2B6 activity.

Li-Chen Gao, Fang-Qun Liu, Li Yang, Lin Cheng, Hai-Ying Dai, Ran Tao, Shi-Peng Cao, Di Wang, Jie Tang

Abstract readControlled Clinical Trial
PubMed Publisher
In one paragraph

Article in European journal of clinical pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Pharmacogenetic Influence on Stereoselective Steady-State Disposition of Bupropion.Drug metabolism and disposition: the biological fate of chemicals · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Li-Chen GaoDepartment of Pharmacy, Changsha Central Hospital, Changsha, 410004, Hunan, People's Republic of China. gonedog1224@hotmail.com.
Fang-Qun LiuDepartment of Pharmacy, Changsha Central Hospital, Changsha, 410004, Hunan, People's Republic of China.
Li YangDepartment of Pharmacy, Changsha Central Hospital, Changsha, 410004, Hunan, People's Republic of China. yl7618@126.com.
Lin ChengState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, Guangdong, People's Republic of China.
Hai-Ying DaiDepartment of Cardiology, Changsha Central Hospital, Changsha, 410004, Hunan, People's Republic of China.
Ran TaoDepartment of Cardiology, Changsha Central Hospital, Changsha, 410004, Hunan, People's Republic of China.
Shi-Peng CaoTuberculosis Research Center, Pulmonary Hospital, Changsha Central Hospital, Changsha, 410004, Hunan, People's Republic of China.
Di WangDepartment of Oncology, Cancer Institute, Changsha Central Hospital, Changsha, 410004, Hunan, People's Republic of China.
Jie TangInstitute of Clinical Pharmacology, Central South University, Changsha, 410078, Hunan, People's Republic of China.
Changsha Central Hospital · CNCentral South University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate whether single-nucleotide polymorphisms (SNPs) in the P450 oxidoreductase (POR) gene were correlated with interindividual variations in cytochrome P450 (CYP) 2B6 activity.

methodsThirty-six healthy volunteers who tested CYP2B6 and POR polymorphisms were enrolled in the study. CYP2B6 activity was measured by bupropion hydroxylation with LC/MS/MS. The ratio of hydroxybupropion versus bupropion (AUC_hyd/AUC_bup) in terms of area under the time-concentration curve (AUC) was used to represent the CYP2B6 activity.

resultsThe volunteers carrying CYP2B6*1/*1 showed a significantly higher mean AUC_hyd/ AUC_bup than those CYP2B6*1/*6 and CYP2B6*6/*6 variants (15.66 ± 1.65 vs. 9.25 ± 1.92, P = 0.008 and 15.66 ± 1.65 vs. 8.21 ± 1.74, P = 0.006, respectively). POR rs2868177 (6593 A > G) AA homozygotes showed a significantly lower mean AUC_hyd/ AUC_bup than that of POR rs2868177 AG heterozygotes or GG homozygotes (8.13 ± 1.37 vs. 12.15 ± 2.97, P = 0.005 and 8.13 ± 1.37 vs. 17.59 ± 3.25, P = 0.001, respectively). Moreover, POR rs2868177 AG heterozygotes and GG homozygotes showed a significantly increased mean AUC_hyd/AUC_bup than AA homozygotes in the CYP2B6*1/*1 and CYP2B6*6 carriers (16.40 ± 2.01 vs. 12.40 ± 1.45, P = 0.006 and 10.65 ± 1.47 vs. 6.54 ± 1.25, P = 0.004, respectively). Meanwhile, a strong correlation between the genetic variations (POR rs2868177 and CYP2B6*6) and AUC_hyd/ AUC_bup was found (P = 0.009 and P = 0.001, respectively). There was no significant difference in the mean AUC_hyd/AUC_bup among different POR *28 genotypes (P > 0.05).

conclusionPOR rs2868177 and CYP2B6*6 variants contribute to the interindividual variability in human CYP2B6 activity, which may affect the disposition and interaction of other CYP2B6 substrate drugs.

Indexed as

AdultArea Under CurveAsian PeopleBupropionCytochrome P-450 CYP2B6Cytochrome P-450 Enzyme SystemGene FrequencyGenotypeHealthy VolunteersHumansHydroxylationMalePolymorphism, Single NucleotideYoung AdultBupropionCYP2B6 protein, humanCytochrome P-450 CYP2B6Cytochrome P-450 Enzyme SystemhydroxybupropionPOR protein, humanBupropion hydroxylationCYP2B6Interindividual variationsP450 oxidoreductasePolymorphism

Identifiers

PMID27439448
OpenAlexW2489633386

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.