Evidence map›Paper›PMID 27439420›Full record

ArticleMaternal and child health journal2017

Cumulative Physiologic Dysfunction and Pregnancy: Characterization and Association with Birth Outcomes.

Kimberly Schmitt McKee, Christopher Seplaki, Susan Fisher, Susan W Groth, I Diana Fernandez

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Maternal and child health journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Allostatic Load, Neighborhood Disadvantage, and Birth Outcomes.Journal of racial and ethnic health disparities · 2026
    Article
  5. Review
  6. Review
  7. Acknowledging and Addressing Allostatic Load in Pregnancy Care.Journal of racial and ethnic health disparities · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kimberly Schmitt McKeeDepartment of Public Health Sciences, University of Rochester Medical Center, 265 Crittenden Blvd., Rochester, NY, 14642, USA. kimckee@med.umich.edu.ORCID 0000-0002-2905-5000
Christopher SeplakiDepartment of Public Health Sciences, University of Rochester Medical Center, 265 Crittenden Blvd., Rochester, NY, 14642, USA.
Susan FisherTemple Clinical Research Institute, Department of Clinical Sciences, Temple University School of Medicine, Kresge Science Hall, Second Floor, 3440 N. Broad Street, Philadelphia, PA, 19140, USA.
Susan W GrothSchool of Nursing, University of Rochester Medical Center, 255 Crittenden Blvd. Box SON, Rochester, NY, 14642, USA.
I Diana FernandezDepartment of Public Health Sciences, University of Rochester Medical Center, 265 Crittenden Blvd., Rochester, NY, 14642, USA.

Funding

RESEARCH TRAINING IN PREVENTIVE CARDIOLOGYT32HL007937 · NHLBI · UNIVERSITY OF ROCHESTER · PI LOWENSTEIN, CHARLES J · 2000 to 2014
$7.1M
Electronically-Mediated Weight Interventions for Pregnant and Postpartum WomenU01HL096760 · NHLBI · CORNELL UNIVERSITY · PI FERNANDEZ, ISABEL DIANA, OLSON, CHRISTINE MARIE · 2009 to 2013
$4.5M
Aging-Related Biodemography of Life Course Physiology and Environmental ModifiersK01AG031332 · NIA · UNIVERSITY OF ROCHESTER · PI SEPLAKI, CHRISTOPHER · 2009 to 2013
$609k
NHLBI NIH HHS T32 HL007937NHLBI NIH HHS U01 HL096760NIA NIH HHS K01 AG031332
6 · The paper itself

Abstract

Objective To characterize cumulative physiologic dysfunction (CPD) in pregnancy as a measure of the biological effects of chronic stress and to examine its associations with gestational age and birth weight. Methods Women ≤28 weeks gestation were enrolled from obstetric clinics in Rochester, NY and followed through their delivery. CPD parameters included total cholesterol, Interleukin 6 (IL-6), high sensitivity-C-reactive protein (hs-CRP), systolic and diastolic blood pressure, body mass index at <14 weeks gestation, glucose tolerance, and urinary albumin collected in the third trimester. Linear regression was used to estimate the association between physiologic dysfunction and birth weight and gestational age, respectively (N = 111). Results CPD scores ranged from 0 to 6, out of a total of 8 parameters (Mean 2.09; SD = 1.42). Three-fourths of the participants had a CPD score of 3.0 or lower. The mean birth weight was 3397 g (SD = 522.89), and the mean gestational age was 39.64 weeks (SD = 1.08). CPD was not significantly associated with either birth weight or gestational age (p = 0.42 and p = 0.44, respectively). Conclusion CPD measured at >28 weeks was not associated with birth weight or gestational age. Refinement of a CPD score for pregnancy is needed, taking into consideration both the component parameters and clinical and pre-clinical cut-points for risk scoring.

Indexed as

AdultAllostasisAnalysis of VarianceBirth WeightBlood PressureBody ConstitutionBody Mass IndexC-Reactive ProteinFemaleGestational AgeHumansInfant, NewbornInterleukin-6Linear ModelsNew YorkParturitionC-Reactive ProteinIL6 protein, humanInterleukin-6Allostatic loadBirth weightCumulative physiologic dysfunctionGestational agePregnancy

Identifiers

PMID27439420
PMCPMC5389895

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.