Evidence map›Paper›PMID 27439376›Full record

ArticleBMC infectious diseases2016

Disparities in HIV clinic care across Europe: findings from the EuroSIDA clinic survey.

Jeffrey V Lazarus, Kamilla Grønborg Laut, Kelly Safreed-Harmon, Lars Peters, Margaret Johnson, Gerd Fätkenheuer, Irina Khromova, Linos Vandekerckhove, Katarzyna Maciejewska, Roxana Radoi and 2 more

Abstract read
In one paragraph

Article in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jeffrey V LazarusCHIP - Centre for Health and Infectious Disease Research, Rigshospitalet, University of Copenhagen, Øster Alle 56, 5. sal, DK-2100, Copenhagen, Denmark. Jeffrey.Lazarus@regionh.dk.
Kamilla Grønborg LautCHIP - Centre for Health and Infectious Disease Research, Rigshospitalet, University of Copenhagen, Øster Alle 56, 5. sal, DK-2100, Copenhagen, Denmark.
Kelly Safreed-HarmonCHIP - Centre for Health and Infectious Disease Research, Rigshospitalet, University of Copenhagen, Øster Alle 56, 5. sal, DK-2100, Copenhagen, Denmark.
Lars PetersCHIP - Centre for Health and Infectious Disease Research, Rigshospitalet, University of Copenhagen, Øster Alle 56, 5. sal, DK-2100, Copenhagen, Denmark.
Margaret JohnsonRoyal Free and University College Medical School, London, United Kingdom.
Gerd FätkenheuerUniversity Hospital Cologne, Cologne, Germany.
Irina KhromovaCentre for HIV/AIDS and infectious diseases, Kaliningrad, Russian Federation.
Linos VandekerckhoveHIV Translational Research Unit (HTRU), Department of Internal Medicine, Ghent University and Ghent University Hospital, Ghent, Belgium.
Katarzyna MaciejewskaDepartment of Infectious, Tropical Diseases and Aquired Immunodeficiencies of Pomeranian Medical University, Szczecin, Poland.
Roxana RadoiDr. Victor Babes Hospital, Bucharest, Romania.
Anna Lisa RidolfoClinica delle Malattie Infettive, Milan, Italy.
Amanda MocroftDepartment of Infection and Population Health, University College London, London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough advances in HIV medicine have yielded increasingly better treatment outcomes in recent years, HIV-positive people with access to antiretroviral therapy (ART) still face complex health challenges. The EuroSIDA Study Group surveyed its clinics to explore regional differences in clinic services.

methodsThe EuroSIDA study is a prospective observational cohort study that began enrolling patients in 1994. In early 2014, we conducted a 59-item survey of the 98 then-active EuroSIDA clinics. The survey covered HIV clinical care and other aspects of patient care. The EuroSIDA East Europe study region (Belarus, Estonia, Lithuania, the Russian Federation and Ukraine) was compared to a "non-East Europe" study region comprised of all other EuroSIDA countries.

resultsA larger proportion of clinics in the East Europe group reported deferring ART in asymptomatic patients until the CD4 cell count dropped below 350 cells/mm(3) (75 % versus 25 %, p = 0.0032). Considerably smaller proportions of East Europe clinics reported that resistance testing was provided before ART initiation (17 % versus 86 %, p < 0.0001) and that it was provided upon treatment failure (58 % versus 90 %, p = 0.0040). Only 33 % of East Europe clinics reported providing hepatitis B vaccination, compared to 88 % of other clinics (p < 0.0001). Only 50 % of East Europe clinics reported having access to direct-acting antivirals for hepatitis C treatment, compared to 89 % of other clinics (p = 0.0036). There was significantly less tuberculosis/HIV treatment integration in the East Europe group (27 % versus 84 % p < 0.0001) as well as significantly less screening for cardiovascular disease (58 % versus 90 %, p = 0.014); tobacco use (50 % versus 93 %, p < 0.0001); alcohol consumption (50 % versus 93 %, p < 0.0001); and drug use (58 % versus 87 %, p = 0.029).

conclusionsStudy findings demonstrate how specific features of HIV clinics differ across Europe. Significantly more East Europe clinics deferred ART in asymptomatic patients for longer, and significantly fewer East Europe clinics provided resistance testing before initiating ART or upon ART failure. The East Europe group of clinics also differed in regard to hepatitis B vaccination, direct-acting antiviral access, tuberculosis/HIV treatment integration and screening for other health issues. There is a need for further research to guide setting-specific decision-making regarding the optimal array of services at HIV clinics in Europe and worldwide.

Indexed as

Ambulatory Care FacilitiesAdultAlcohol DrinkingAnti-HIV AgentsAntiviral AgentsCD4 Lymphocyte CountCohort StudiesEuropeFemaleHepatitis CHIV InfectionsHumansMaleMiddle AgedProspective StudiesSmokingAnti-HIV AgentsAntiviral AgentsAIDSEuropeHealth care deliveryHealth systemsHIV

Identifiers

PMID27439376
PMCPMC4955207

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.