Evidence map›Paper›PMID 27439221›Full record

Observational studyInternational journal of cancer2016

Physical activity and sedentary behavior in relation to lung cancer incidence and mortality in older women: The Women's Health Initiative.

Ange Wang, FeiFei Qin, Haley Hedlin, Manisha Desai, Rowan Chlebowski, Scarlett Gomez, Charles B Eaton, Karen C Johnson, Lihong Qi, Jean Wactawski-Wende and 3 more

Open access · bronzeAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 5 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 5 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
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  3. Physical Activity in Cancer Prevention and Survival: A Systematic Review.Medicine and science in sports and exercise · 2019
    Pooled it
  4. Barriers and facilitators of exercise experienced by cancer survivors: a mixed methods systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
    Pooled it
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  20. Leisure-Time Physical Activity and Cancer Risk Among Older Adults: A Cohort Study.Mayo Clinic proceedings. Innovations, quality & outcomes · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 1 country.

Ange WangDivision of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA.
FeiFei QinQuantitative Sciences Unit, Stanford University School of Medicine, Palo Alto, CA.
Haley HedlinQuantitative Sciences Unit, Stanford University School of Medicine, Palo Alto, CA.
Manisha DesaiQuantitative Sciences Unit, Stanford University School of Medicine, Palo Alto, CA.
Rowan ChlebowskiLos Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA.
Scarlett GomezCancer Prevention Institute of California, Fremont, CA.
Charles B EatonDepartment of Family Medicine, Memorial Hospital of Rhode Island, and Department of Epidemiology, School of Public Health at Brown University, Providence, RI.
Karen C JohnsonDepartment of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN.
Lihong QiDepartment of Public Health Sciences, University of California Davis, Davis, CA.
Jean Wactawski-WendeDepartment of Social and Preventive Medicine, University at Buffalo, Buffalo, NY.
Catherine WomackDepartment of Internal Medicine, University of Tennessee Health Science Center, Memphis, TN.
Heather A WakeleeDivision of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA.
Marcia L StefanickDepartment of Medicine, Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA. stefanick@stanford.edu.
Palo Alto University · USStanford Medicine · USStanford University · USUniversity of Tennessee Health Science Center · USBrown University · USCancer Prevention Institute of California · USThe Lundquist Institute · USUniversity at Buffalo, State University of New York · USUniversity of California, Davis · US

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Melinda L. Telli · 2007 to 2026
$71.4M
NCI NIH HHS P30 CA124435NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNIA NIH HHS HHSN271201100004CWHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

Physical activity has been associated with lower lung cancer incidence and mortality in several populations. We investigated these relationships in the Women's Health Initiative Observational Study (WHI-OS) and Clinical Trial (WHI-CT) prospective cohort of postmenopausal women. The WHI study enrolled 161,808 women aged 50-79 years between 1993 and 1998 at 40 U.S. clinical centers; 129,401 were eligible for these analyses. Cox proportional hazards models were used to assess the association of baseline physical activity levels [metabolic equivalent (MET)-min/week: none <100 (reference), low 100 to <500, medium 500 to <1,200, high 1,200+] and sedentary behavior with total lung cancer incidence and mortality. Over 11.8 mean follow-up years, 2,148 incident lung cancer cases and 1,365 lung cancer deaths were identified. Compared with no activity, higher physical activity levels at study entry were associated with lower lung cancer incidence [p = 0.009; hazard ratios (95% confidence intervals) for each physical activity category: low, HR: 0.86 (0.76-0.96); medium, HR: 0.82 (0.73-0.93); and high, HR: 0.90 (0.79-1.03)], and mortality [p < 0.0001; low, HR: 0.80 (0.69-0.92); medium, HR: 0.68 (0.59-0.80); and high, HR: 0.78 (0.66-0.93)]. Body mass index (BMI) modified the association with lung cancer incidence (p = 0.01), with a stronger association in women with BMI < 30 kg/m(2) . Significant associations with sedentary behavior were not observed. In analyses by lung cancer subtype, higher total physical activity levels were associated with lower lung cancer mortality for both overall NSCLC and adenocarcinoma. In conclusion, physical activity may be protective for lung cancer incidence and mortality in postmenopausal women, particularly in non-obese women.

Indexed as

ExerciseSedentary BehaviorAgedAge FactorsCohort StudiesFemaleHumansIncidenceLung NeoplasmsMiddle AgedProportional Hazards ModelsProspective StudiesRandomized Controlled Trials as TopicWomen's Healthexerciseincidencelung cancermortalityphysical activitysedentary behaviorWomen's Health Initiative

Identifiers

PMID27439221
PMCPMC5501309
OpenAlexW2494018109

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.