Evidence map›Paper›PMID 27438862›Full record

ReviewBiosensors2016

MIPs and Aptamers for Recognition of Proteins in Biomimetic Sensing.

Marcus Menger, Aysu Yarman, Júlia Erdőssy, Huseyin Bekir Yildiz, Róbert E Gyurcsányi, Frieder W Scheller

Open access · goldAbstract readReview
In one paragraph

Review in Biosensors, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 67 citations in OpenAlex.

  1. Article
  2. Review
  3. Machine-Learning-Aided Advanced Electrochemical Biosensors.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Aptamer Sensors.Biosensors · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Marcus MengerFraunhofer Institute for Cell Therapy and Immunology, Branch Bioanalytics and Bioprocesses (IZI-BB), Am Mühlenberg 13, Potsdam D-14476, Germany. marcus.menger@izi-bb.fraunhofer.de.
Aysu YarmanInstitute of Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Strasse 25-26, Potsdam D-14476, Germany. aysu.yarman@yahoo.de.
Júlia ErdőssyMTA-BME "Lendület" Chemical Nanosensors Research Group, Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szent Gellért tér 4, Budapest H-1111, Hungary. julia.erdossy@gmail.com.
Huseyin Bekir YildizDepartment of Materials Science and Nanotechnology Engineering, KTO Karatay University, Konya 42020, Turkey. bilgi@karatay.edu.tr.
Róbert E GyurcsányiMTA-BME "Lendület" Chemical Nanosensors Research Group, Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szent Gellért tér 4, Budapest H-1111, Hungary. robertgy@mail.bme.hu.
Frieder W SchellerFraunhofer Institute for Cell Therapy and Immunology, Branch Bioanalytics and Bioprocesses (IZI-BB), Am Mühlenberg 13, Potsdam D-14476, Germany. fschell@uni-potsdam.de.
Budapest University of Technology and Economics · HUUniversity of Potsdam · DEFraunhofer Institute for Cell Therapy and Immunology · DEKTO Karatay University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomimetic binders and catalysts have been generated in order to substitute the biological pendants in separation techniques and bioanalysis. The two major approaches use either "evolution in the test tube" of nucleotides for the preparation of aptamers or total chemical synthesis for molecularly imprinted polymers (MIPs). The reproducible production of aptamers is a clear advantage, whilst the preparation of MIPs typically leads to a population of polymers with different binding sites. The realization of binding sites in the total bulk of the MIPs results in a higher binding capacity, however, on the expense of the accessibility and exchange rate. Furthermore, the readout of the bound analyte is easier for aptamers since the integration of signal generating labels is well established. On the other hand, the overall negative charge of the nucleotides makes aptamers prone to non-specific adsorption of positively charged constituents of the sample and the "biological" degradation of non-modified aptamers and ionic strength-dependent changes of conformation may be challenging in some application.

Indexed as

Aptamers, NucleotideBiomimeticsBiosensing TechniquesMolecular ImprintingPolymersProteinsCatalysisProtein BindingReproducibility of ResultsAptamers, NucleotidePolymersProteinsaptamersaptasensorsbiomimetic recognition elementschemical sensorsin vitro selectionmolecularly imprinted polymersSELEX

Identifiers

PMID27438862
PMCPMC5039654
OpenAlexW2484316520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.