ArticleMolecules (Basel, Switzerland)2016
An Expeditious and Greener Synthesis of 2-Aminoimidazoles in Deep Eutectic Solvents.
Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 55 citations in OpenAlex.
- Green synthesis of imidazole derivatives in a ternary deep eutectic solvent system.Scientific reports · 2025Article
- A Sustainable Synthetic Approach to Tacrine and Cholinesterase Inhibitors in Deep Eutectic Solvents under Aerobic Conditions.Molecules (Basel, Switzerland) · 2024Article
- The impact of counterions in biological activity: case study of antibacterial alkylguanidino ureas.Molecular diversity · 2023Article
- Review
- Selective Aerobic Oxidation of Alcohols in Low Melting Mixtures and Water and Use for Telescoped One-Pot Hybrid Reactions.ChemistryOpen · 2022Article
- A green synthesis and antibacterial activity of ferrocene-based thiazole derivatives in choline chloride/glycerol eutectic solvent.RSC advances · 2022Article
- Deep Eutectic Solvents in Solar Energy Technologies.Molecules (Basel, Switzerland) · 2022Review
- Ligand-Free Copper-Catalyzed Ullmann-Type C-O Bond Formation in Non-Innocent Deep Eutectic Solvents under Aerobic Conditions.ChemSusChem · 2022Article
- Deep Eutectic Solvents as Effective Reaction Media for the Synthesis of 2-Hydroxyphenylbenzimidazole-based Scaffolds en Route to Donepezil-Like Compounds.Molecules (Basel, Switzerland) · 2020Article
- Regiodivergent synthesis of functionalized pyrimidines and imidazoles through phenacyl azides in deep eutectic solvents.Beilstein journal of organic chemistry · 2020Article
- Biorenewable Deep Eutectic Solvent for Selective and Scalable Conversion of Furfural into Cyclopentenone Derivatives.Molecules (Basel, Switzerland) · 2018Article
- Deep Eutectic Solvents as Convenient Media for Synthesis of Novel Coumarinyl Schiff Bases and Their QSAR Studies.Molecules (Basel, Switzerland) · 2017Article
- Special Issue: "Organic Reactions in Green Solvents".Molecules (Basel, Switzerland) · 2016Article
- Deep Eutectic Solvent-Based Microwave-Assisted Method for Extraction of Hydrophilic and Hydrophobic Components from Radix Salviae miltiorrhizae.Molecules (Basel, Switzerland) · 2016Article
- Towards the development of continuous, organocatalytic, and stereoselective reactions in deep eutectic solvents.Beilstein journal of organic chemistry · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A high-yield one-pot two-step synthesis of 2-aminoimidazoles (2-AI), exploiting an under-air heterocyclodehydration process between α-chloroketones and guanidine derivatives, and using deep eutectic solvents (DESs) as nonconventional, "green" and "innocent" reaction media, has been accomplished successfully. The combination of either glycerol or urea with choline chloride (ChCl) proved to be effective for decreasing the reaction time to about 4-6 h in contrast to the 10-12 h usually required for the same reaction run in toxic and volatile organic solvents and under an argon atmosphere. In addition, the use of the ChCl-urea as a DES also enables the direct isolation of triaryl-substituted 2-AI derivatives by means of a simple work-up procedure consisting in filtration and crystallization, and allows the recycle of the DES mixture. A plausible mechanism highlighting the potential role played by hydrogen bonding catalysis has also been illustrated.
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