ArticleNeuroradiology2016
Determinants of leptomeningeal collateral flow in stroke patients with a middle cerebral artery occlusion.
Article in Neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Determinants of Leptomeningeal Collateral Status in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis of Observational Studies.Journal of the American Heart Association · 2024Pooled it
- Meta-Analysis of Prognostic Correlation of Thrombectomy for Cerebral Infarction Based on Intelligent Medical Treatment.BioMed research international · 2022Pooled it
- Association between circle of Willis and ischemic stroke: a systematic review and meta-analysis.BMC neuroscience · 2021Pooled it
- Time to Endovascular Treatment and Clinical Outcome in Acute Ischemic Stroke With M2-Segment Occlusion.Journal of the American Heart Association · 2025Trial
- Contralateral Neurovascular Coupling in Patients with Ischemic Stroke After Endovascular Thrombectomy.Neurocritical care · 2025Article
- Sanctuary sites in cortical stroke.Frontiers in neurology · 2025Article
- The Prognostic Value of a Naples Score in Determining in-Hospital Mortality in Patients with Acute Ischemic Stroke Undergoing Endovascular Treatment.Journal of clinical medicine · 2024Article
- Modeling cerebrovascular responses to assess the impact of the collateral circulation following middle cerebral artery occlusion.Microcirculation (New York, N.Y. : 1994) · 2024Article
- White matter hyperintensity burden and collateral circulation in acute ischemic stroke with large artery occlusion.BMC neurology · 2024Article
- Recruitment of pial collaterals and carotid occlusive disease in large-vessel occlusion ischemic stroke.Frontiers in neurology · 2024Article
- A collateral circulation in ischemic stroke accelerates recanalization due to lower clot compaction.PloS one · 2024Article
- Review
- Volumetric Flow Assessment in Extracranial Arteries in Patients with 70-99% Internal Carotid Artery Stenosis.Diagnostics (Basel, Switzerland) · 2022Article
- Role of diabetes in collateral status assessed in CT perfusion-derived dynamic CTA in anterior circulation stroke.Neuroradiology · 2022Article
- Clinical and radiological factors predicting stroke outcome after successful mechanical intervention in anterior circulation.European heart journal supplements : journal of the European Society of Cardiology · 2022Article
- Intracranial Flow Volume Estimation in Patients with Internal Carotid Artery Occlusion.Diagnostics (Basel, Switzerland) · 2022Article
- The Hyperdense middle cerebral artery sign is associated with poor leptomeningeal collaterals in acute ischemic stroke: a retrospective study.BMC neurology · 2022Article
- Reduced Leukoaraiosis, Noncardiac Embolic Stroke Etiology, and Shorter Thrombus Length Indicate Good Leptomeningeal Collateral Flow in Embolic Large-Vessel Occlusion.AJNR. American journal of neuroradiology · 2022Article
- Corneal nerve loss as a surrogate marker for poor pial collaterals in patients with acute ischemic stroke.Scientific reports · 2021Article
- ColorViz, a New and Rapid Tool for Assessing Collateral Circulation during Stroke.Brain sciences · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPoor leptomeningeal collateral flow is related to worse clinical outcome in acute ischemic stroke, but the factors that determine leptomeningeal collateral patency are largely unknown. We explored the determinants of leptomeningeal collateral flow and assessed their effect on the relation between leptomeningeal collateral flow and clinical outcome.
methodsWe included 484 patients from the Dutch acute stroke study (DUST) with a middle cerebral artery (MCA) occlusion. The determinants of poor leptomeningeal collateral flow (≤50 % collateral filling) were identified with logistic regression. We calculated the relative risk (RR) of poor leptomeningeal collateral flow in relation to poor clinical outcome (90-day modified Rankin Scale 3-6) using Poisson regression and assessed whether the determinants of leptomeningeal collateral flow affected this relation.
resultsLeptomeningeal collateral flow was poor in 142 patients (29 %). In multivariable analyses, higher admission glucose level (odds ratio (OR) 1.1 per mmol/L increase (95 % CI 1.0-1.2)), a proximal MCA occlusion (OR 1.9 (95 % CI 1.3-3.0)), and an incomplete posterior circle of Willis (OR 1.7 (95 % CI 1.1-2.6)) were independently related to poor leptomeningeal collateral flow. Poor leptomeningeal collateral flow was related to poor clinical outcome (unadjusted RR 1.7 (95 % CI 1.4-2.0)), and this relation was not affected by the determinants of leptomeningeal collateral flow.
conclusionOur study shows that admission glucose level, a proximal MCA occlusion, and an incomplete ipsilateral posterior circle of Willis are determinants of leptomeningeal collateral flow that represent a combination of congenital, acquired, and acute factors. After adjustment for these determinants, leptomeningeal collateral flow remains related to clinical outcome.
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