ArticlePloS one2016
Impact of Helminth Infections and Nutritional Constraints on the Small Intestine Microbiota.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- MICHELINdb: a web-based tool for mining of helminth-microbiota interaction datasets, and a meta-analysis of current research.Microbiome · 2020Pooled it
- Parasites and allergies: a complex bidirectional relationship from evolutionary origins to modern therapeutics.Antonie van Leeuwenhoek · 2026Review
- Coprophagy in Healthy Dogs Does Not Alter Fecal Core Microbiota or Increase Carriage of Enteropathogens.Animals : an open access journal from MDPI · 2026Article
- High prevalence of soil-transmitted helminths among primary students in Ha Giang, Vietnam: A descriptive cross-sectional study.Medicine · 2025Article
- Interaction between methanotrophy and gastrointestinal nematodes infection on the rumen microbiome of lambs.FEMS microbiology ecology · 2024Article
- Article
- Urinary neopterin reflects immunological variation associated with age, helminth parasitism, and the microbiome in a wild primate.Scientific reports · 2022Article
- Excretory-secretory products from the brown stomach worm, Teladorsagia circumcincta, exert antimicrobial activity in in vitro growth assays.Parasites & vectors · 2022Article
- Food for thought - ILC metabolism in the context of helminth infections.Mucosal immunology · 2022Review
- Changes in the Diversity and Composition of Gut Microbiota of Red-Crowned Cranes (Animals : an open access journal from MDPI · 2022Article
- Increasing helminth infection burden depauperates the diversity of the gut microbiota and alters its composition in mice.Current research in parasitology & vector-borne diseases · 2022Article
- Prevalence of Intestinal Helminths among Cancer Patients Who Are under Chemotherapy at the University of Gondar Comprehensive Specialized Hospital Oncology Clinic, Northwest Ethiopia.Journal of cancer epidemiology · 2022Article
- Article
- Coinfection and infection duration shape how pathogens affect the African buffalo gut microbiota.The ISME journal · 2021Article
- Vaccination against the brown stomach worm, Teladorsagia circumcincta, followed by parasite challenge, induces inconsistent modifications in gut microbiota composition of lambs.Parasites & vectors · 2021Article
- A Comparison of the Colonic Microbiome and Volatile Organic Compound Metabolome ofAnimals : an open access journal from MDPI · 2021Article
- Article
- Eukaryotic and Prokaryotic Microbiota Interactions.Microorganisms · 2020Review
- Natural Infection withmSphere · 2020Article
- Intestinal parasites in rural communities in Nan Province, Thailand: changes in bacterial gut microbiota associated with minute intestinal fluke infection.Parasitology · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helminth infections and nutrition can independently alter the composition and abundance of the gastrointestinal microbiota, however, their combined effect is poorly understood. Here, we used the T. retortaeformis-rabbit system to examine how the helminth infection and host restriction from coprophagy/ready-to-absorb nutrients affected the duodenal microbiota, and how these changes related to the acquired immune response at the site of infection. A factorial experiment was performed where the bacterial community, its functionality and the immune response were examined in four treatments (Infect, Infect+Collar, Control+Collar and Control). Helminths reduced the diversity and abundance of the microbiota while the combination of parasites and coprophagic restriction led to a more diversified and abundant microbiota than infected cases, without significantly affecting the intensity of infection. Animals restricted from coprophagy and free from parasites exhibited the richest and most abundant bacterial community. By forcing the individuals to absorb nutrients from less digested food, the coprophagic restriction appears to have facilitated the diversity and proliferation of bacteria in the duodenum. Changes in the microbiota were more clearly associated with changes in the immune response for the infected than the nutrient restricted animals. The functional and metabolic characteristics of the duodenal microbiota were not significantly different between treatments. Overall, infection and diet affect the gut microbiota but their interactions and outcome can be complex. These findings can have important implications for the development of control measures to helminth infections where poor nutrition/malnutrition can also be a concern.
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