Evidence map›Paper›PMID 27438627›Full record

Trial reportJournal of anesthesia2016

Effects of oral carbohydrate with amino acid solution on the metabolic status of patients in the preoperative period: a randomized, prospective clinical trial.

Rie Tsutsumi, Nami Kakuta, Takako Kadota, Takuro Oyama, Katsuyoshi Kume, Eisuke Hamaguchi, Noriko Niki, Katsuya Tanaka, Yasuo M Tsutsumi

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of anesthesia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Rie TsutsumiDepartment of Nutrition, Tokushima University, Tokushima, Japan.
Nami KakutaDepartment of Anesthesiology, Tokushima University, Tokushima, Japan.
Takako KadotaDepartment of Anesthesiology, Tokushima University, Tokushima, Japan.
Takuro OyamaDepartment of Anesthesiology, Tokushima University, Tokushima, Japan.
Katsuyoshi KumeDepartment of Anesthesiology, Tokushima University, Tokushima, Japan.
Eisuke HamaguchiDepartment of Anesthesiology, Tokushima University, Tokushima, Japan.
Noriko NikiDepartment of Anesthesiology, Tokushima University, Tokushima, Japan.
Katsuya TanakaDepartment of Anesthesiology, Tokushima University, Tokushima, Japan.
Yasuo M TsutsumiDepartment of Anesthesiology, Tokushima University, Tokushima, Japan. tsutsumi@tokushima-u.ac.jp.
Tokushima University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveEnhanced recovery after surgery is increasingly desired nowadays, and preoperative nutrient intake may be beneficial for this purpose. In this study, we investigated whether the intake of preoperative carbohydrate with amino acid (ONS) solution can improve starvation status and lipid catabolism before the induction of anesthesia.

methodsThis randomized, prospective clinical trial included 24 patients who were divided into two groups before surgery under general anesthesia: a control group, comprising patients who fasted after their last meal the day before surgery (permitted to drink only water), and an ONS group, comprising patients who consumed ONS solution 2 h before surgery. Biochemical markers, the respiratory quotient, and psychosomatic scores were assessed at the initiation of anesthesia.

resultsCompared with the control group, the ONS group showed significantly lower serum free fatty acid levels [control group: 828 (729, 1004) µEq/L, ONS group: 479 (408, 610) µEq/L, P = 0.0002, median (25th, 75th percentile)] and total ketone bodies [control group: 119 (68, 440) µmol/L, ONS group: 40 [27, 64] µmol/L, P = 0.037]. In addition, analysis using the Visual Analog Scale showed higher preoperative scores for anxiety, hunger, and thirst for the control group, with no differences in any other measure of subjective well-being between groups.

conclusionsThe results of this study suggest that preoperative ONS intake improves lipid catabolism and starvation status before the induction of anesthesia. Furthermore, it can provide better preoperative mental health compared with complete fasting.

Indexed as

Administration, OralAdultAgedAged, 80 and overAmino AcidsAnesthesia, GeneralAnxietyCarbohydratesFemaleHumansHungerKetone BodiesLipid MetabolismMaleMetabolismMiddle AgedAmino AcidsCarbohydratesKetone BodiesEnhanced recovery after surgeryNutritional statusPreoperative carbohydrateQuality of lifeSurgical outcomes

Identifiers

PMID27438627
PMCPMC5034005
OpenAlexW2494491190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.