ArticleClinics (Sao Paulo, Brazil)2016
The effects of smoking and smoking cessation on nasal mucociliary clearance, mucus properties and inflammation.
Article in Clinics (Sao Paulo, Brazil), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02136550 (Smoking Cessation on the Human Airway), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Smoking Cessation on the Human Airway: Mucus Secretion, Inflammatory and Proteomic Profile in Nasal Lavage and miRNAs in Blood
Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Inadequate preoperative smoking cessation fails to improve outcomes after esophagectomy.Journal of cardiothoracic surgery · 2026Article
- Systemic predictors of symptom burden in CRSsNP: a cross-sectional comparison of three patient-reported outcome measures.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Adverse events with monitored anesthesia care sedation in patients with stroke receiving mechanical thrombectomy.Orthopedic reviews · 2026Article
- Age, lifestyle, and disease affect ciliary transport in the human fallopian tube.Scientific reports · 2025Article
- Differences in respiratory wheezing between current exclusive e-cigarette users, current exclusive cigarette smokers, and never users of either product: findings from a population-based study.Harm reduction journal · 2025Article
- Effect of Smoking on Electron Microscopic Structure of Nasal Mucosa.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- Longitudinal Effects of 1-Year Smoking Cessation on Human Bronchial Epithelial Transcriptome.Chest · 2023Article
- Impact of smoking on nasal mucociliary clearance time in Kano metropolis, Nigeria.World journal of otorhinolaryngology - head and neck surgery · 2023Article
- Examining the evidence for the health impact of combustion-free products: progress and prospects for tobacco harm reversal and reduction.Internal and emergency medicine · 2021Article
- Nasal Mucociliary Clearance in Smokers: A Systematic Review.International archives of otorhinolaryngology · 2021Review
- Impact of exclusive e-cigarettes and heated tobacco products use on muco-ciliary clearance.Therapeutic advances in chronic disease · 2021Article
- Smoking load reduction is insufficient to downregulate miR-301b, a lung cancer promoter.Scientific reports · 2020Article
- Anisakis Sensitization in the Croatian fish processing workers: Behavioral instead of occupational risk factors?PLoS neglected tropical diseases · 2020Article
- COVID's Razor: RAS Imbalance, the Common Denominator Across Disparate, Unexpected Aspects of COVID-19.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
- Tobacco craving and withdrawal symptoms in psychiatric patients during a motivational enhancement intervention based on a 26-hour smoking abstinence period.Tobacco prevention & cessation · 2019Article
- Hookah smoking impairs nasal mucociliary clearance.Tobacco induced diseases · 2018Article
- Cocaine Reduces Ciliary Beat Frequency of Human Nasal Epithelial Cells.In vivo (Athens, Greece)Article
- Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of the present study was to assess nasal mucociliary clearance, mucus properties and inflammation in smokers and subjects enrolled in a Smoking Cessation Program (referred to as quitters).
methodA total of 33 subjects with a median (IQR) smoking history of 34 (20-58) pack years were examined for nasal mucociliary clearance using a saccharine transit test, mucus properties using contact angle and sneeze clearability tests, and quantification of inflammatory and epithelial cells, IL-6 and IL-8 concentrations in nasal lavage fluid. Twenty quitters (mean age: 51 years, 9 male) were assessed at baseline, 1 month, 3 months and 12 months after smoking cessation, and 13 smokers (mean age: 52 years, 6 male) were assessed at baseline and after 12 months. Clinicaltrials.gov: NCT02136550.
resultsSmokers and quitters showed similar demographic characteristics and morbidities. At baseline, all subjects showed impaired nasal mucociliary clearance (mean 17.6 min), although 63% and 85% of the quitters demonstrated significant nasal mucociliary clearance improvement at 1 month and 12 months, respectively. At 12 months, quitters also showed mucus sneeze clearability improvement (∼26%), an increased number of macrophages (2-fold) and no changes in mucus contact angle or cytokine concentrations.
conclusionThis study showed that smoking cessation induced early improvements in nasal mucociliary clearance independent of mucus properties and inflammation. Changes in mucus properties were observed after only 12 months of smoking cessation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.