ArticlePloS one2016
Time-Course Study of the Transcriptome of Peripheral Blood Mononuclear Cells (PBMCs) from Sheep Infected with Fasciola hepatica.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Deciphering theBiomolecules · 2025Review
- Helminth/Protozoan Coinfections in Chronic Fascioliasis Cases in Human Hyperendemic Areas: High Risk of Multiparasitism Linked to Transmission Aspects and Immunological, Environmental and Social Factors.Tropical medicine and infectious disease · 2025Article
- Comparative proteomic profiling of the ovine and human PBMC inflammatory response.Scientific reports · 2024Article
- Evaluation of the Role of Galectins in Parasite Immunity.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Developmental Regulation and Functional Prediction of microRNAs in an ExpandedFrontiers in cellular and infection microbiology · 2022Article
- Transcriptomic Analysis of Ovine Hepatic Lymph Node FollowingFrontiers in immunology · 2021Article
- Timing of Transcriptomic Peripheral Blood Mononuclear Cell Responses of Sheep toFrontiers in immunology · 2021Article
- Characterization of dendritic cells and follicular dendritic cells in the hepatic lymph nodes and liver of sheep experimentally infected with Fasciola hepatica.Veterinary research · 2020Article
- An Evaluation of theFrontiers in immunology · 2020Review
- Global serum proteomic changes in water buffaloes infected with Fasciola gigantica.Parasites & vectors · 2019Article
- Genome-wide association study of endo-parasite phenotypes using imputed whole-genome sequence data in dairy and beef cattle.Genetics, selection, evolution : GSE · 2019Article
- Article
- Comparative dynamics of peritoneal cell immunophenotypes in sheep during the early and late stages of the infection with Fasciola hepatica by flow cytometric analysis.Parasites & vectors · 2018Article
- An ex vivo ruminal ovine model to study the immediate immune response in the context of bacterial lipopolysaccharide.Functional & integrative genomics · 2018Article
- Infection by the Helminth ParasiteMolecular & cellular proteomics : MCP · 2018Article
- Immune signatures of pathogenesis in the peritoneal compartment during early infection of sheep with Fasciola hepatica.Scientific reports · 2017Article
- Transcriptomic responses of water buffalo liver to infection with the digenetic fluke Fasciola gigantica.Parasites & vectors · 2017Article
- Network Analysis of the Systemic Response toFrontiers in immunology · 2017Article
- Transcriptomic Study on Ovine Immune Responses to Fasciola hepatica Infection.PLoS neglected tropical diseases · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fasciola hepatica is a parasitic trematode that infects a wide range of mammalian hosts, including livestock and humans, in temperate and tropical regions globally. This trematode causes the disease fascioliasis, which consists of an acute phase (≤ 12 weeks) during which juvenile parasites migrate through the host liver tissues, and a chronic phase (> 12 weeks) following the establishment of adult parasites in the liver bile ducts. Few studies have explored the progression of the host response over the course of Fasciola infection in the same animals. In this study, we characterized transcriptomic changes in peripheral blood mononuclear cells (PBMCs) collected from sheep at three time points over the first eight weeks of infection relative to uninfected controls. In total, 183 and 76 genes were found to be differentially transcribed at two and eight weeks post-infection respectively. Functional and pathway analysis of differentially transcribed genes revealed changes related to T-cell activation that may underpin a Th2-biased immune response against this parasite. This first insight into the dynamics of host responses during the early stages of infection improves the understanding of the pathogenesis of acute fascioliasis, informs vaccine development and presents a set of PBMC markers with diagnostic potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.