ReviewCurrent allergy and asthma reports2016
New Insights Into the Relationship Between Chitinase-3-Like-1 and Asthma.
Review in Current allergy and asthma reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Immunomodulatory Significance of Mast Cell Exosomes (MC-EXOs) in Immune Response Coordination.Clinical reviews in allergy & immunology · 2025Review
- Respiratory symptoms, sensitisation and occupational exposure in the shrimp processing industry.Frontiers in allergy · 2025Article
- Neurodegeneration Biomarkers in Adult Spinal Muscular Atrophy (SMA) Patients Treated with Nusinersen.International journal of molecular sciences · 2024Article
- Significance of Mast Cell Formed Extracellular Traps in Microbial Defense.Clinical reviews in allergy & immunology · 2022Review
- Adenovirus vector-mediated YKL-40 shRNA attenuates eosinophil airway inflammation in a murine asthmatic model.Gene therapy · 2021Article
- C. elegans as a new tractable host to study infections by animal pathogenic oomycetes.PLoS pathogens · 2021Article
- K284-6111 alleviates memory impairment and neuroinflammation in Tg2576 mice by inhibition of Chitinase-3-like 1 regulating ERK-dependent PTX3 pathway.Journal of neuroinflammation · 2020Article
- The nasal methylome as a biomarker of asthma and airway inflammation in children.Nature communications · 2019Article
- Mast Cell-Mediated Orchestration of the Immune Responses in Human Allergic Asthma: Current Insights.Clinical reviews in allergy & immunology · 2019Review
- Overexpression of chitotriosidase and YKL-40 in peripheral blood and sputum of healthy smokers and patients with chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2019Article
- Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs.JCI insight · 2018Article
- Chitin and Its Effects on Inflammatory and Immune Responses.Clinical reviews in allergy & immunology · 2018Review
- Chitinase-3-Like Protein 1 (YKL-40) Reflects the Severity of Symptoms in Atopic Dermatitis.Journal of immunology research · 2017Article
- Genetic Variants Associated with Bronchial Asthma Specific to the Population of the Russian Federation.Acta naturaeArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewCHI3L1 (also known as YKL-40), a member of "mammalian chitinase-like proteins," is a serum protein lacking enzymatic activity. Although the protein is highly conserved in mammals, a consensus regarding its role in human pathologies is currently lacking. In an attempt to shed light on the many physiological functions of the protein, specifically with regard to asthma, a comprehensive overview of recent studies is provided. RECENT
findingsIn asthma, CHI3L1 is secreted from macrophages and airway epithelial cells through an IL-13 related mechanism. Th2-associated inflammatory responses due to allergen exposure, resulting in airway hyper-responsiveness and smooth muscle contraction, play a role in tissue remodeling. The importance of CHI3L1 in initiation and development of asthma is not limited to its involvement in highly orchestrated events of inflammatory cytokines but further research is needed for further elucidation. Levels of the protein are associated with severity for numerous pathologies, including asthma, suggesting limited specificity as a biomarker.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.