← Statins × cardiac & vascular function

TrialJAMA cardiology2016

Effect of Targeting Inflammation With Salsalate: The TINSAL-CVD Randomized Clinical Trial on Progression of Coronary Plaque in Overweight and Obese Patients Using Statins.

Thomas H Hauser et al.PubMed ↗Publisher ↗

  • Salsalateno clear effectNo clear effect on noncalcified plaque volume.Nothing cleared the noise.

What the trial testedas reported · 257 people · 2016

Range includes no effect

No clear effect on noncalcified plaque volume

−1.00−11.0 to +9.00

salsalate vs placebo

As reported

difference −1, 95% CI −11.0 to 9.00 · the paper's word: change in noncalcified plaque volume

Range includes no effect

No clear effect on cardiac & vascular function

+3.00−11.0 to +9.00

As reported

difference 3, 95% CI −11.0 to 9.00

Who was studied, and how

340people in the Targeting Inflammation Using Salsalate in CardioVascular Disease trial, from 2008
257of them with obesity, in this paper

The trial randomly assignedassigned by chance

salsalate
placebo

No clear effect on noncalcified plaque volume−1.00

randomised

the abstract, start to end

… and placebo groups (mean difference, -1 mm3; 95% CI, -11 to 9 mm3; …

← favours treatmentfavours comparator →
could be chance
Change in noncalcified plaque volumesalsalate vs placebo
−1−11.0 to 9.00
Cardiac & vascular function
3−11.0 to 9.00
StatinsCardiac & vascular function

Statins × cardiac & vascular functionhelps?mixed

unlikelylikely
0.500.50 without it
← favours treatmentfavours comparator →
this papermore certainless certain
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29 papers cite it

2016
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this paperpooled ittrialcites it

The trial

Full record →Abstract, authors, funding and every citing paper · PMID 27438317