Evidence map›Paper›PMID 27438073›Full record

ArticleClinical and experimental nephrology2017

Association between medication adherence and clinical outcomes in patients with chronic kidney disease: a prospective cohort study.

Mayuree Tangkiatkumjai, Dawn-Marie Walker, Kearkiat Praditpornsilpa, Helen Boardman

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Clinical and experimental nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04616612 (Medication Adherence Given Individual SystemCHANGE), which is not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04616612 nacompletednot on this mapstarted 2021, after this paper: background citation

Medication Adherence Given Individual SystemCHANGE(TM) in Advancing Nephropathy (MAGICIAN) Pilot Study

TypeinterventionalSponsorIndiana UniversityRan2021 to 2024Enrolled150ConditionsChronic Kidney Disease(CKD)ArmsSystemCHANGE (TM), Attention Control
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.

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  10. Assessment of Dietary Folate Intake and Pill Burden among Saudi Patients on Maintenance Hemodialysis.International journal of environmental research and public health · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Mayuree TangkiatkumjaiDivision of Clinical Pharmacy, Faculty of Pharmacy, Srinakharinwirot University, Nakhonnayok, 26120, Thailand. mayureet@g.swu.ac.th.
Dawn-Marie WalkerSchool of Health Sciences, University of Southampton, Southampton, UK.
Kearkiat PraditpornsilpaDivision of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Helen BoardmanDivision of Social Research in Medicines and Health, School of Pharmacy, University of Nottingham, Nottingham, UK.
Chulalongkorn University · THSrinakharinwirot University · THUniversity of Nottingham · GBUniversity of Southampton · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is limited evidence of medication adherence related to progression of chronic kidney disease (CKD) worldwide. The aim of this study was to determine associations between medication adherence and the progression of CKD in outpatients with CKD.

methodsThis cohort study recruited 339 Thai patients with stages 3-5 CKD. Patients with a glomerular disease or receiving renal replacement therapy before recruitment were excluded. 295 were followed up regarding their serum creatinine, blood pressure, glycated hemoglobin, and low-density lipoprotein cholesterol over 12 months. Medication adherence was measured at baseline using the Thai version of the 8-Item Morisky Medication Adherence Scale

resultsTwenty-one percent had poor adherence. Younger patients were more likely to have poor adherence (adjusted OR 2.81, 95 % CI 1.45-5.43). Anti-hypertensive agents were the most frequently reported as not being taken (52 %). Patients with poor adherence were associated with the progression of CKD (adjusted OR 1.96, 95 % CI 1.02-3.76). Those with poor adherence were less likely to control their blood pressure, than moderate-to-high adherence group (p < 0.01).

conclusionThe findings suggest that CKD patients with poor medication adherence are more likely to have progression of CKD. Health care providers should acknowledge these findings and provide effective strategies to deal with this issue.

Indexed as

Medication AdherenceAgedAged, 80 and overAntihypertensive AgentsBiomarkersBlood PressureChi-Square DistributionCholesterol, LDLCreatinineDisease ProgressionDyslipidemiasFemaleGlomerular Filtration RateGlucose Metabolism DisordersGlycated HemoglobinHumansAntihypertensive AgentsBiomarkersCholesterol, LDLCreatinineGlycated Hemoglobinhemoglobin A1c protein, humanHypoglycemic AgentsHypolipidemic AgentsChronic kidney diseaseClinical outcomesMedication adherenceProgressionThailand

Identifiers

PMID27438073
OpenAlexW2490624905

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.