Evidence map›Paper›PMID 27438041›Full record

SynthesisArquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery

COST-EFFECTIVENESS OF PERIOPERATIVE IMMUNONUTRITION IN GASTROINTESTINAL ONCOLOGIC SURGERY: A SYSTEMATIC REVIEW.

Audrey Machado Dos Reis, Geórgia Brum Kabke, Ana Valéria Gonçalves Fruchtenicht, Taiane Dias Barreiro, Luis Fernando Moreira

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Immunonutrition for patients undergoing surgery for head and neck cancer.The Cochrane database of systematic reviews · 2018
    Pooled it
  2. Review
  3. Review
  4. Targeted nutritional strategies in postoperative care.Anesthesia and pain medicine · 2025
    Review
  5. Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Audrey Machado Dos ReisMultidisciplinary Integrated Health in Critical Adult Residency Program.
Geórgia Brum KabkeSouthern Surgical Oncology Research Group and Post-Graduate Program of Surgery, Faculty of Medicine, Rio Grande do Sul Federal University and Department of Surgery, Hospital de Clínicas de Porto Alegre University Attached Hospital, Porto alegre, RS, Brazil.
Ana Valéria Gonçalves FruchtenichtSouthern Surgical Oncology Research Group and Post-Graduate Program of Surgery, Faculty of Medicine, Rio Grande do Sul Federal University and Department of Surgery, Hospital de Clínicas de Porto Alegre University Attached Hospital, Porto alegre, RS, Brazil.
Taiane Dias BarreiroSouthern Surgical Oncology Research Group and Post-Graduate Program of Surgery, Faculty of Medicine, Rio Grande do Sul Federal University and Department of Surgery, Hospital de Clínicas de Porto Alegre University Attached Hospital, Porto alegre, RS, Brazil.
Luis Fernando MoreiraSouthern Surgical Oncology Research Group and Post-Graduate Program of Surgery, Faculty of Medicine, Rio Grande do Sul Federal University and Department of Surgery, Hospital de Clínicas de Porto Alegre University Attached Hospital, Porto alegre, RS, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCosts, length of hospital staying and morbidity are frequently and significantly increased as a result of infections and other complications following surgical procedure for gastrointestinal tract cancer. Recently, improving host defence mechanisms have become a target of interest. Immunonutrition aims at improving immunity, most likely providing key nutrients to maintain T-lymphocyte and other host defence.

aimTo evaluate the immunonutrition in cancer patients who are operated by digestive diseases and assess the cost-effectiveness of this supplementation.

methodsThis study consisted of a systematic review of the literature based on reference analyses retrieved from current databases such as PubMed, Lilacs and SciELO. The search strategy was defined by terms related to immunonutrition [immunonutrition, arginine, omega-3 and nucleotides] in combination with [costs, cost-effective and cost-effectiveness] as well as [gastrointestinal cancer surgery, oesophageal, gastric or pancreatic surgery] in English, Portuguese or Spanish language. For cost analyses, currencies used in the manuscripts were all converted to American dollars (US$) in order to uniform and facilitate comparison. Six prospective randomized studies were included in this review.

conclusionThe cost-effectiveness was positive in most of studies, demonstrating that this diet can significantly reduce hospital costs in the North hemisphere. However, similar studies needed to be carried to determine such results among us.

Indexed as

Cost-Benefit AnalysisDietDigestive System Surgical ProceduresGastrointestinal NeoplasmsHumansImmunotherapyPerioperative Care

Identifiers

PMID27438041
PMCPMC4944750

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.