Evidence map›Paper›PMID 27437924›Full record

Observational studyThe international journal of cardiovascular imaging2018

Myocardial tissue remodeling after orthotopic heart transplantation: a pilot cardiac magnetic resonance study.

Otavio Rizzi Coelho-Filho, Ravi Shah, Carlos Fernando Ramos Lavagnoli, Jose Carlos Barros, Tomas G Neilan, Venkatesh L Murthy, Pedro Paulo Martins de Oliveira, Jose Roberto Matos Souza, Elaine Soraya Barbosa de Oliveira Severino, Karlos Alexandre de Souza Vilarinho and 6 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in The international journal of cardiovascular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

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  11. Cardiovascular imaging 2018 in the International Journal of Cardiovascular Imaging.The international journal of cardiovascular imaging · 2019
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  14. Histological validation of cardiovascular magnetic resonance T1 mapping markers of myocardial fibrosis in paediatric heart transplant recipients.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Otavio Rizzi Coelho-FilhoFaculty of Medical Science, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil. orcfilho@unicamp.br.ORCID http://orcid.org/0000-0003-4428-5186
Ravi ShahBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Carlos Fernando Ramos LavagnoliFaculty of Medical Science, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Jose Carlos BarrosFaculty of Medical Science, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Tomas G NeilanMassaschussetts General Hospital, Harvard Medical School, Boston, MA, USA.
Venkatesh L MurthyCardiovascular Medicine Division, Department of Medicine, University of Michigan, Ann Arbor, MI, USA.
Pedro Paulo Martins de OliveiraFaculty of Medical Science, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Jose Roberto Matos SouzaFaculty of Medical Science, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Elaine Soraya Barbosa de Oliveira SeverinoFaculty of Medical Science, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Karlos Alexandre de Souza VilarinhoFaculty of Medical Science, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Lindemberg da Mota Silveira FilhoFaculty of Medical Science, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Jose GarciaMassaschussetts General Hospital, Harvard Medical School, Boston, MA, USA.
Marc J SemigranMassaschussetts General Hospital, Harvard Medical School, Boston, MA, USA.
Otavio Rizzi CoelhoFaculty of Medical Science, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Michael Jerosch-HeroldNoninvasive Cardiovascular Imaging Program, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Orlando PetrucciFaculty of Medical Science, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Universidade Estadual de Campinas (UNICAMP) · BRHarvard University · USBeth Israel Deaconess Medical Center · USBrigham and Women's Hospital · USMichigan Medicine · US

Funding

CNPq 303366/2015-0
6 · The paper itself

Abstract

After orthotopic heart transplantation (OHT), the allograft undergoes characteristic alterations in myocardial structure, including hypertrophy, increased ventricular stiffness, ischemia, and inflammation, all of which may decrease overall graft survival. Methods to quantify these phenotypes may clarify the pathophysiology of progressive graft dysfunction post-OHT. We performed cardiac magnetic resonance (CMR) with T1 mapping in 26 OHT recipients (mean age 47 ± 7 years, 30 % female, median follow-up post-OHT 6 months) and 30 age-matched healthy volunteers (mean age 50.5 ± 15 years; LVEF 63.5 ± 7 %). OHT recipients had a normal left ventricular ejection fraction (LVEF 65.3 ± 11 %) with higher LV mass relative to age-matched healthy volunteers (114 ± 27 vs. 85.8 ± 18 g; p < 0.001). There was no late gadolinium enhancement in either group. Both myocardial extracellular volume fraction (ECV) and intracellular lifetime of water (τ

Indexed as

Heart TransplantationMagnetic Resonance Imaging, CineVentricular Function, LeftVentricular RemodelingAdultAgedAllograftsBiopsyCardiomegalyCase-Control StudiesCross-Sectional StudiesFemaleFibrosisGraft RejectionGraft SurvivalHumansExtracellular volume fractionFibrosisGadolinium-DTPAHypertrophyMagnetic resonance imaging and orthotopic heart transplantation

Identifiers

PMID27437924
OpenAlexW2506410464

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.